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Tbio
DIABLO
Diablo homolog, mitochondrial

Protein Summary
Description
Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyn ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353548
  • ENSP00000320343
  • ENSG00000184047
  • ENST00000443649
  • ENSP00000398495
  • ENSG00000284934
  • ENST00000464942
  • ENSP00000442360

Symbol
  • SMAC
  • SMAC
  • DFNA64
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.98
chemical
0.9
transcription factor perturbation
0.88
biological term
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1370.41   (req: < 5)
Gene RIFs: 134   (req: <= 3)
Antibodies: 666   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1370.41   (req: >= 5)
Gene RIFs: 134   (req: > 3)
Antibodies: 666   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (142)
BIRC2
Tchem
Novelty:  0.00199701
p_int:  0.99999986
p_ni:  1.4e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
XIAP
Tchem
Family:  Enzyme
Novelty:  0.00062268
p_int:  0.999997123
p_ni:  0.000002544
p_wrong:  3.33e-7
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
DUSP22
Tbio
Family:  Enzyme
Novelty:  0.01579003
p_int:  0.999996954
p_ni:  2.65e-7
p_wrong:  0.000002781
Data Source:  BioPlex
BIRC7
Tchem
Novelty:  0.00420245
p_int:  0.999560991
p_ni:  0.000439009
Score:  0.956
Data Source:  BioPlex,STRINGDB
TRAF2
Tbio
Novelty:  0.00983658
p_int:  0.999386677
p_ni:  0.000613323
Score:  0.965
Data Source:  BioPlex,STRINGDB
MTFR1
Tbio
Novelty:  0.14089765
p_int:  0.99574513
p_ni:  0.00425487
Score:  0.197
Data Source:  BioPlex,STRINGDB
BIRC8
Tchem
Novelty:  0.05142518
p_int:  0.993750372
p_ni:  0.006249628
Score:  0.927
Data Source:  BioPlex,STRINGDB
BIRC6
Tbio
Novelty:  0.01187953
p_int:  0.99347646
p_ni:  0.00652354
Score:  0.957
Data Source:  BioPlex,STRINGDB
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.981258318
p_ni:  0.018741682
Data Source:  BioPlex
TRAF1
Tbio
Novelty:  0.00526776
p_int:  0.966775913
p_ni:  0.033223985
p_wrong:  1.03e-7
Score:  0.794
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (54)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic factor-mediated response
Reactome
Cytochrome c-mediated apoptotic response
Reactome
Formation of apoptosome
Reactome
Intrinsic Pathway for Apoptosis
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic factor-mediated response
Cytochrome c-mediated apoptotic response
Formation of apoptosome
Intrinsic Pathway for Apoptosis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
11
12
90.9
BMI-adjusted waist-hip ratio
1
9
9
86.2
waist-hip ratio
1
9
9
84.2
high density lipoprotein cholesterol measurement
1
2
2
79.2
serum alanine aminotransferase measurement
1
1
0
10.3
76.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
12
90.9
BMI-adjusted waist-hip ratio
9
86.2
waist-hip ratio
9
84.2
high density lipoprotein cholesterol measurement
2
79.2
serum alanine aminotransferase measurement
0
10.3
76.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913843
66593
Rat
RGD:2321120
100360940
Dog
diablo IAP-binding mitochondrial protein
VGNC:39954
477463
Horse
diablo IAP-binding mitochondrial protein
VGNC:17182
100058709
Cow
diablo IAP-binding mitochondrial protein
VGNC:28061
493999
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
diablo IAP-binding mitochondrial protein
Horse
diablo IAP-binding mitochondrial protein
Cow
diablo IAP-binding mitochondrial protein
Publication Statistics
PubMed Score 1370.41
PubMed score by year
PubTator Score 624.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title