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Tdark
DHX40
Probable ATP-dependent RNA helicase DHX40

Protein Summary
Description
Probable ATP-dependent RNA helicase. This gene encodes a member of the DExH/D box family of ATP-dependent RNA helicases that have an essential role in RNA metabolism. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251241
  • ENSP00000251241
  • ENSG00000108406
  • ENST00000425628
  • ENSP00000388749

Symbol
  • DDX40
  • PAD
  • DDX40
  • ARG147
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
kinase perturbation
0.98
protein domain
0.92
histone modification site profile
0.91
transcription factor
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.04   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.04   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
PPIL4
Tdark
Family:  Enzyme
Novelty:  0.3737992
p_int:  0.999999892
p_ni:  1.08e-7
Score:  0.231
Data Source:  BioPlex,STRINGDB
HERC1
Tbio
Family:  Enzyme
Novelty:  0.04318441
p_int:  0.999806434
p_ni:  0.000193566
Data Source:  BioPlex
USP7
Tchem
Family:  Enzyme
Novelty:  0.00412878
p_int:  0.999582913
p_ni:  0.000417087
Score:  0.173
Data Source:  BioPlex,STRINGDB
TRIM27
Tbio
Novelty:  0.02102013
p_int:  0.999370468
p_ni:  0.000629529
p_wrong:  3e-9
Data Source:  BioPlex
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.999326095
p_ni:  0.000673905
Data Source:  BioPlex
NUDCD1
Tbio
Novelty:  0.07471096
p_int:  0.996849193
p_ni:  0.003150807
Data Source:  BioPlex
ECE2
Tchem
Family:  Enzyme
Novelty:  0.03234301
p_int:  0.99246903
p_ni:  0.00753097
Score:  0.394
Data Source:  BioPlex,STRINGDB
EPM2AIP1
Tdark
Novelty:  0.1803524
p_int:  0.992373489
p_ni:  0.007626511
Score:  0.54
Data Source:  BioPlex,STRINGDB
GPSM3
Tbio
Novelty:  0.01632501
p_int:  0.932195505
p_ni:  0.067804494
p_wrong:  1e-9
Data Source:  BioPlex
ATXN7L1
Tdark
Novelty:  0.43694835
p_int:  0.901514144
p_ni:  0.098485711
p_wrong:  1.44e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
1
1
35
creatinine measurement
1
1
1
35
platelet count
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
35
creatinine measurement
1
35
platelet count
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAH-box helicase 40
VGNC:9256
454809
Mouse
MGI:1914737
67487
Rat
RGD:1359618
287595
Dog
DEAH-box helicase 40
VGNC:39949
480577
Cow
DEAH-box helicase 40
VGNC:28056
533484
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAH-box helicase 40
Mouse
Rat
Dog
DEAH-box helicase 40
Cow
DEAH-box helicase 40
Publication Statistics
PubMed Score 3.04
PubMed score by year
PubTator Score 12.89
PubTator score by year
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Related Publications
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PMID
Year
Title