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Tbio
DHX33
ATP-dependent RNA helicase DHX33

Protein Summary
Description
Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity) (PubMed:21930779, PubMed:23871209, PubMed:26100019). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment (PubMed:21930779). In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation (PubMed:26100019). Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells (PubMed:23871209). Required for NLRP3 activation induced by viral dsRNA and bacterial RNA (PubMed:23871209). In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways (By similarity). This gene encodes a member of the DEAD box protein family. The DEAD box proteins are ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225296
  • ENSP00000225296
  • ENSG00000005100

Symbol
  • DDX33
  • DDX33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.92
transcription factor binding site profile
0.78
transcription factor perturbation
0.74
microRNA
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.71   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.71   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (258)
USP36
Tbio
Family:  Enzyme
Novelty:  0.02779727
p_int:  0.999951106
p_ni:  0.000048894
Score:  0.821
Data Source:  BioPlex,STRINGDB
DMWD
Tbio
Novelty:  0.04096001
p_int:  0.998338961
p_ni:  0.001661025
p_wrong:  1.4e-8
Data Source:  BioPlex
POTEI
Tdark
Novelty:  0.41311202
p_int:  0.976745177
p_ni:  0.023254823
Data Source:  BioPlex
RUFY3
Tbio
Novelty:  0.1517817
p_int:  0.960618201
p_ni:  0.039381799
Data Source:  BioPlex
SLC35F2
Tbio
Family:  Transporter
Novelty:  0.08323418
p_int:  0.756808539
p_ni:  0.243191456
p_wrong:  5e-9
Data Source:  BioPlex
DDX49
Tbio
Family:  Enzyme
Novelty:  0.14100169
Score:  0.984
Data Source:  STRINGDB
NLRP3
Tchem
Novelty:  0.00043957
Score:  0.977
Data Source:  STRINGDB
NOM1
Tbio
Novelty:  0.02627848
Score:  0.969
Data Source:  STRINGDB
DDX56
Tbio
Family:  Enzyme
Novelty:  0.03330582
Score:  0.967
Data Source:  STRINGDB
DIEXF
Tbio
Novelty:  0.05892659
Score:  0.967
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
2
2
86.1
body mass index
8
3
9
85.2
myeloid white cell count
1
1
1
78.1
leukocyte count
1
1
1
73.9
neutrophil count
2
1
2
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
86.1
body mass index
9
85.2
myeloid white cell count
1
78.1
leukocyte count
1
73.9
neutrophil count
2
64.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAH-box helicase 33
VGNC:9255
468453
Macaque
DEAH-box helicase 33
711977
Mouse
MGI:2445102
216877
Rat
RGD:1307239
287464
Dog
DEAH-box helicase 33
VGNC:39943
607226
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAH-box helicase 33
Macaque
DEAH-box helicase 33
Mouse
Rat
Dog
DEAH-box helicase 33
Publication Statistics
PubMed Score 17.71
PubMed score by year
PubTator Score 6.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title