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Tbio
DHX32
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32

Protein Summary
Description
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates 2 transcript variants, but the full length nature of one of the variants has not been defined. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
tissue sample
0.72
disease perturbation
0.68
trait
0.61
cell type or tissue
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.52   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.52   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (231)
LIPH
Tbio
Family:  Enzyme
Novelty:  0.00961658
p_int:  0.999987661
p_ni:  0.000012323
p_wrong:  1.6e-8
Score:  0.527
Data Source:  BioPlex,STRINGDB
ZNF785
Tdark
Family:  TF
Novelty:  0.42629766
p_int:  0.999854215
p_ni:  0.000143099
p_wrong:  0.000002686
Score:  0.153
Data Source:  BioPlex,STRINGDB
NUDCD1
Tbio
Novelty:  0.07471096
p_int:  0.999594304
p_ni:  0.000405696
Score:  0.831
Data Source:  BioPlex,STRINGDB
MRPL16
Tdark
Novelty:  0.38562971
p_int:  0.99911627
p_ni:  0.00088373
Score:  0.268
Data Source:  BioPlex,STRINGDB
ZNF136
Tdark
Family:  TF
Novelty:  0.68698067
p_int:  0.997663883
p_ni:  0.002333634
p_wrong:  0.000002483
Data Source:  BioPlex
ZBBX
Tdark
Novelty:  1.66474399
p_int:  0.878520573
p_ni:  0.011007338
p_wrong:  0.11047209
Score:  0.173
Data Source:  BioPlex,STRINGDB
POLRMT
Tbio
Family:  Enzyme
Novelty:  0.01398067
p_int:  0.792607817
p_ni:  0.207392183
Score:  0.256
Data Source:  BioPlex,STRINGDB
DDX49
Tbio
Family:  Enzyme
Novelty:  0.14100169
Score:  0.92
Data Source:  STRINGDB
BCCIP
Tbio
Novelty:  0.02710491
Score:  0.913
Data Source:  STRINGDB
DDX27
Tbio
Family:  Enzyme
Novelty:  0.20604441
Score:  0.868
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
70.2
red blood cell distribution width
1
1
1
44.2
appendicular lean mass
1
1
1
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
70.2
red blood cell distribution width
1
44.2
appendicular lean mass
1
0.8
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAH-box helicase 32 (putative)
VGNC:7845
736293
Macaque
DEAH-box helicase 32 (putative)
695919
Mouse
MGI:2141813
101437
Rat
RGD:1311740
361667
Dog
DEAH-box helicase 32 (putative)
VGNC:52988
100685023
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAH-box helicase 32 (putative)
Macaque
DEAH-box helicase 32 (putative)
Mouse
Rat
Dog
DEAH-box helicase 32 (putative)
Publication Statistics
PubMed Score 13.52
PubMed score by year
PubTator Score 9.25
PubTator score by year
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Related Publications
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PMID
Year
Title