Tbio DHX29 ATP-dependent RNA helicase DHX29

Protein Summary

Description

ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity. This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• Q7Z478
• O75549
• Q63HN0
• Q63HN3
• Q8IWW2
• Q8N3A1
• Q9UMH2

Gene Name

• DHX29

Ensembl ID

• ENST00000251636
• ENSP00000251636
• ENSG00000067248

Symbol

• DDX29
• DDX29

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
protein domain	0.92
histone modification site profile	0.89
cell type or tissue	0.67
cell line	0.58

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Rna Helicase / Atp-dependent Rna Helicase Dhx29

Protein / Nucleic Acid Binding / Rna Binding Protein / Rna Helicase / Atp-dependent Rna Helicase Dhx29

DTO Classes

Protein / Enzyme / Helicase / Rna Helicase / Atp-dependent Rna Helicase Dhx29

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.89   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 88   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.89   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0