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Tbio
DHTKD1
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Protein Summary
Description
The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). This gene encodes a component of a mitochondrial 2-oxoglutarate-dehydrogenase-complex-like protein involved in the degradation pathways of several amino acids, including lysine. Mutations in this gene are associated with 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth Disease Type 2Q. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263035
  • ENSP00000263035
  • ENSG00000181192

Symbol
  • KIAA1630
  • CMT2Q
  • AMOXAD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.77
cell type or tissue
0.68
transcription factor perturbation
0.68
cell line
0.65
molecular function
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.83   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.83   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
PGLYRP3
Tbio
Novelty:  0.04880521
p_int:  0.999998162
p_ni:  0.000001777
p_wrong:  6.1e-8
Score:  0.513
Data Source:  BioPlex,STRINGDB
ARNTL2
Tbio
Family:  TF
Novelty:  0.0039351
p_int:  0.999671475
p_ni:  0.000328366
p_wrong:  1.6e-7
Score:  0.196
Data Source:  BioPlex,STRINGDB
DENR
Tbio
Novelty:  0.00653432
p_int:  0.997285543
p_ni:  0.002714441
p_wrong:  1.6e-8
Score:  0.165
Data Source:  BioPlex,STRINGDB
RIMKLA
Tdark
Family:  Enzyme
Novelty:  0.30213465
p_int:  0.996253657
p_ni:  0.003746045
p_wrong:  2.98e-7
Score:  0.564
Data Source:  BioPlex,STRINGDB
DGKG
Tbio
Family:  Enzyme
Novelty:  0.03666646
p_int:  0.995749298
p_ni:  0.004250678
p_wrong:  2.4e-8
Data Source:  BioPlex
FAHD1
Tbio
Family:  Enzyme
Novelty:  0.07873941
p_int:  0.97378783
p_ni:  0.025189448
p_wrong:  0.001022722
Score:  0.249
Data Source:  BioPlex,STRINGDB
MORN5
Tdark
Novelty:  1.51123721
p_int:  0.959975495
p_ni:  0.039653767
p_wrong:  0.000370737
Score:  0.325
Data Source:  BioPlex,STRINGDB
ICAM1
Tchem
Novelty:  0.00009746
p_int:  0.929373635
p_ni:  0.059121738
p_wrong:  0.011504627
Data Source:  BioPlex
YBEY
Tdark
Family:  Enzyme
Novelty:  0.02778029
p_int:  0.880977141
p_ni:  0.118129849
p_wrong:  0.00089301
Score:  0.151
Data Source:  BioPlex,STRINGDB
GATC
Tbio
Family:  Enzyme
Novelty:  0.62484697
p_int:  0.82409199
p_ni:  0.175513156
p_wrong:  0.000394854
Score:  0.173
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Glyoxylate metabolism and glycine degradation (R-HSA-389661)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
1
2
77.1
glucose measurement
1
1
1
71
1
1
0
1.2
67.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
77.1
glucose measurement
1
71
0
1.2
67.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dehydrogenase E1 and transketolase domain containing 1
VGNC:1030
736115
Mouse
MGI:2445096
209692
Rat
RGD:1308092
361272
Dog
dehydrogenase E1 and transketolase domain containing 1
VGNC:39938
478008
Horse
dehydrogenase E1 and transketolase domain containing 1
VGNC:17170
100056844
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dehydrogenase E1 and transketolase domain containing 1
Mouse
Rat
Dog
dehydrogenase E1 and transketolase domain containing 1
Horse
dehydrogenase E1 and transketolase domain containing 1
Publication Statistics
PubMed Score 30.83
PubMed score by year
PubTator Score 7.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title