Tbio DHTKD1 Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial

Protein Summary

Description

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). This gene encodes a component of a mitochondrial 2-oxoglutarate-dehydrogenase-complex-like protein involved in the degradation pathways of several amino acids, including lysine. Mutations in this gene are associated with 2-aminoadipic 2-oxoadipic aciduria and Charcot-Marie-Tooth Disease Type 2Q. [provided by RefSeq, May 2013]

Uniprot Accession IDs

• Q96HY7
• Q68CU5
• Q9BUM8
• Q9HCE2

Gene Name

• DHTKD1

Ensembl ID

• ENST00000263035
• ENSP00000263035
• ENSG00000181192

Symbol

• KIAA1630
• CMT2Q
• AMOXAD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.77
cell type or tissue	0.68
transcription factor perturbation	0.68
cell line	0.65
molecular function	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.74   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 117   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.74   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0