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Tbio
DHRS9
Dehydrogenase/reductase SDR family member 9

Protein Summary
Description
3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH. This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357546
  • ENSP00000350154
  • ENSG00000073737
  • ENST00000412271
  • ENSP00000407747
  • ENST00000421653
  • ENSP00000388066
  • ENST00000428522
  • ENSP00000388564
  • ENST00000432060
  • ENSP00000389241
  • ENST00000436483
  • ENSP00000407167
  • ENST00000602501
  • ENSP00000473337

Symbol
  • RDH15
  • SDR9C4
  • RDHL
  • RDH15
  • RDH-E2
  • RDHTBE
  • SDR9C4
  • RDH-TBE
  • RETSDR8
  • 3ALPHA-HSD
  • 3-alpha-HSD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
virus perturbation
0.83
cellular component
0.67
transcription factor
0.61
gene perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 392.16   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 392.16   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
CHIC2
Tbio
Novelty:  0.02452235
p_int:  0.99999992
p_ni:  1e-9
p_wrong:  8e-8
Score:  0.516
Data Source:  BioPlex,STRINGDB
EMB
Tbio
Novelty:  0.00135577
p_int:  0.997145736
p_ni:  0.002849958
p_wrong:  0.000004306
Score:  0.163
Data Source:  BioPlex,STRINGDB
SLC16A10
Tbio
Family:  Transporter
Novelty:  0.02363735
p_int:  0.96932143
p_ni:  0.01879788
p_wrong:  0.01188069
Score:  0.163
Data Source:  BioPlex,STRINGDB
MFSD4B
Tdark
Novelty:  0.03380333
p_int:  0.927578194
p_ni:  0.025853563
p_wrong:  0.046568243
Score:  0.201
Data Source:  BioPlex,STRINGDB
GALNT11
Tbio
Family:  Enzyme
Novelty:  0.09714947
p_int:  0.91812778
p_ni:  0.081872219
p_wrong:  2e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.898042895
p_ni:  0.101957028
p_wrong:  7.8e-8
Score:  0.211
Data Source:  BioPlex,STRINGDB
SLC2A8
Tbio
Family:  Transporter
Novelty:  0.02075375
p_int:  0.895183299
p_ni:  0.104797872
p_wrong:  0.000018829
Score:  0.201
Data Source:  BioPlex,STRINGDB
TTYH3
Tbio
Family:  IC
Novelty:  0.21747247
p_int:  0.8693266
p_ni:  0.130673395
p_wrong:  5e-9
Score:  0.226
Data Source:  BioPlex,STRINGDB
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.793425077
p_ni:  0.206574923
Data Source:  BioPlex
MAVS
Tbio
Novelty:  0.00241215
p_int:  0.754915305
p_ni:  0.245049378
p_wrong:  0.000035317
Score:  0.211
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 3 of 3
CYP3A7
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
CYP3A4
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
CYP3A5
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Pathways (11)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
RA biosynthesis pathway
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
RA biosynthesis pathway
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
4
5
5
95.8
serum gamma-glutamyl transferase measurement
3
6
6
94
glomerular filtration rate
5
4
6
92.4
serum alanine aminotransferase measurement
3
3
2
10.7
92.3
low density lipoprotein cholesterol measurement
4
4
4
91.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
5
95.8
serum gamma-glutamyl transferase measurement
6
94
glomerular filtration rate
6
92.4
serum alanine aminotransferase measurement
2
10.7
92.3
low density lipoprotein cholesterol measurement
4
91.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
dehydrogenase/reductase 9
705554
Mouse
MGI:2442798
241452
Rat
RGD:620655
170635
Dog
dehydrogenase/reductase 9
VGNC:39937
488391
Horse
dehydrogenase/reductase 9
VGNC:17169
100052420
Species
Name
OMA
EggNOG
Inparanoid
Macaque
dehydrogenase/reductase 9
Mouse
Rat
Dog
dehydrogenase/reductase 9
Horse
dehydrogenase/reductase 9
Publication Statistics
PubMed Score 392.16
PubMed score by year
PubTator Score 14.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title