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Tbio
DHRS7
Dehydrogenase/reductase SDR family member 7

Protein Summary
Description
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members in this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216500
  • ENSP00000216500
  • ENSG00000100612
  • ENST00000536410
  • ENSP00000442993
  • ENST00000557185
  • ENSP00000451882

Symbol
  • DHRS7A
  • RETSDR4
  • SDR34C1
  • CGI-86
  • SDR34C1
  • retDSR4
  • retSDR4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.95
virus perturbation
0.92
disease perturbation
0.9
transcription factor perturbation
0.8
histone modification site profile
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.15   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.15   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.999999407
p_ni:  5.93e-7
Data Source:  BioPlex
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.99987465
p_ni:  0.00012535
Score:  0.172
Data Source:  BioPlex,STRINGDB
SCN1B
Tbio
Family:  IC
Novelty:  0.00910273
p_int:  0.988381985
p_ni:  0.011614421
p_wrong:  0.000003594
Data Source:  BioPlex
TMEM30A
Tbio
Novelty:  0.05115559
p_int:  0.987877396
p_ni:  0.012122599
p_wrong:  5e-9
Score:  0.362
Data Source:  BioPlex,STRINGDB
SRPRB
Tbio
Novelty:  0.04735362
p_int:  0.986736747
p_ni:  0.013263253
Score:  0.162
Data Source:  BioPlex,STRINGDB
PCDHGA5
Tdark
Novelty:  2.13631603
p_int:  0.98081586
p_ni:  0.01918414
Data Source:  BioPlex
PTGER3
Tclin
Family:  GPCR
Novelty:  0.0012681
p_int:  0.978452952
p_ni:  0.021547048
Data Source:  BioPlex
TGFA
Tbio
Novelty:  0.00216159
p_int:  0.972337246
p_ni:  0.027662751
p_wrong:  3e-9
Data Source:  BioPlex
CPNE5
Tbio
Novelty:  0.09416684
p_int:  0.969841322
p_ni:  0.030158678
Data Source:  BioPlex
PCDHA3
Tdark
Novelty:  0.8622898
p_int:  0.955897193
p_ni:  0.044102807
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
1
1
1
78.1
diastolic blood pressure
1
1
1
12.8
refractive error measurement
1
1
1
4.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
optic disc size measurement
1
78.1
diastolic blood pressure
1
12.8
refractive error measurement
1
4.7
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
dehydrogenase/reductase 7
702872
Mouse
MGI:1913625
66375
Dog
dehydrogenase/reductase 7
VGNC:39935
480342
Horse
dehydrogenase/reductase 7
VGNC:17166
100060062
Cow
dehydrogenase/reductase 7
VGNC:28043
514044
Species
Name
OMA
EggNOG
Inparanoid
Macaque
dehydrogenase/reductase 7
Mouse
Dog
dehydrogenase/reductase 7
Horse
dehydrogenase/reductase 7
Cow
dehydrogenase/reductase 7
Publication Statistics
PubMed Score 7.15
PubMed score by year
PubTator Score 5.94
PubTator score by year
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Related Publications
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PMID
Year
Title