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Tbio
DHRS4L2
Dehydrogenase/reductase SDR family member 4-like 2

Protein Summary
Description
Probable oxidoreductase. This gene encodes a member of the short chain dehydrogenase reductase family. The encoded protein may be an NADPH dependent retinol oxidoreductase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335125
  • ENSP00000334801
  • ENSG00000187630

Symbol
  • SDR25C3
  • SDR25C3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.67
cell line
0.57
histone modification site profile
0.5
tissue
0.48
cellular component
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.84   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.84   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
DHRS4
Tbio
Family:  Enzyme
Novelty:  0.02992279
p_int:  0.999871006
p_ni:  0.000128989
p_wrong:  5e-9
Score:  0.448
Data Source:  BioPlex,STRINGDB
ACOT7
Tbio
Family:  Enzyme
Novelty:  0.01093954
p_int:  0.997620976
p_ni:  0.002379024
Score:  0.338
Data Source:  BioPlex,STRINGDB
D2HGDH
Tbio
Family:  Enzyme
Novelty:  0.04618268
p_int:  0.985690443
p_ni:  0.005650948
p_wrong:  0.008658609
Score:  0.489
Data Source:  BioPlex,STRINGDB
MTIF2
Tbio
Novelty:  0.06681774
p_int:  0.796337129
p_ni:  0.20366287
p_wrong:  1e-9
Score:  0.211
Data Source:  BioPlex,STRINGDB
CYTH4
Tbio
Novelty:  0.05783135
Score:  0.752
Data Source:  STRINGDB
CAVIN2
Tbio
Novelty:  0.00979388
Score:  0.752
Data Source:  STRINGDB
CYTH3
Tbio
Novelty:  0.00940752
Score:  0.722
Data Source:  STRINGDB
ACADS
Tbio
Family:  Enzyme
Novelty:  0.00841051
Score:  0.682
Data Source:  STRINGDB
CYTH2
Tbio
Novelty:  0.03560664
Score:  0.661
Data Source:  STRINGDB
CYTH1
Tbio
Novelty:  0.00635156
Score:  0.639
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 3 of 3
CYP3A5
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
CYP3A7
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
CYP3A4
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
55.2
liver fat measurement
1
1
1
48.5
liver disease biomarker
1
1
1
48.5
cognitive function measurement
1
1
1
17.8
triglyceride measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
55.2
liver fat measurement
1
48.5
liver disease biomarker
1
48.5
cognitive function measurement
1
17.8
triglyceride measurement
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Anole lizard
dehydrogenase/reductase SDR family member 4
100553479
Xenopus
dehydrogenase/reductase (SDR family) member 4
XB-GENE-959123
548501
Species
Name
OMA
EggNOG
Inparanoid
Anole lizard
dehydrogenase/reductase SDR family member 4
Xenopus
dehydrogenase/reductase (SDR family) member 4
Publication Statistics
PubMed Score 31.84
PubMed score by year
PubTator Score 2.08
PubTator score by year
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Related Publications
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PMID
Year
Title