Tbio DHRS3 Short-chain dehydrogenase/reductase 3

Protein Summary

Description

Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH. Short-chain dehydrogenases/reductases (SDRs), such as DHRS3, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 [PubMed 10800688]).[supplied by OMIM, Jun 2009]

Uniprot Accession IDs

• O75911
• B2R7F3
• Q5VUY3
• Q6UY38
• Q9BUC8

Gene Name

• DHRS3

Ensembl ID

• ENST00000616661
• ENSP00000480439
• ENSG00000162496

Symbol

• RDH17
• SDR16C1
• SDR1
• RDH17
• Rsdr1
• DD83.1
• SDR16C1
• retSDR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.98
kinase perturbation	0.98
PubMedID	0.98
disease perturbation	0.9
transcription factor binding site profile	0.9

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.31   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 174   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.31   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0