Tbio DHRS2 Dehydrogenase/reductase SDR family member 2, mitochondrial

Protein Summary

Description

Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21. This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

Uniprot Accession IDs

• Q13268
• D3DS54
• Q53GS4
• Q7Z789
• Q9H2R2

Gene Name

• DHRS2

Ensembl ID

• ENST00000250383
• ENSP00000250383
• ENSG00000100867
• ENST00000344777
• ENSP00000344674
• ENST00000611765
• ENSP00000481607

Symbol

• SDR25C1
• HEP27
• SDR25C1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.95
small molecule perturbation	0.89
cellular component	0.82
interacting protein	0.77
cell type or tissue	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 500.08   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 259   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 500.08   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0