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Tdark
DHRS1
Dehydrogenase/reductase SDR family member 1

Protein Summary
Description
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded enzyme contains a conserved catalytic domain and likely functions as an oxidoreductase. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288111
  • ENSP00000288111
  • ENSG00000157379
  • ENST00000396813
  • ENSP00000380027
  • ENST00000644514
  • ENSP00000496132
  • ENSG00000284868
  • ENST00000647514
  • ENSP00000493735

Symbol
  • SDR19C1
  • SDR19C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.95
disease perturbation
0.9
histone modification site profile
0.76
cell type or tissue
0.72
tissue sample
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (24)
CAVIN2
Tbio
Novelty:  0.00979388
Score:  0.904
Data Source:  STRINGDB
C1orf226
Tdark
Novelty:  3.45031712
Score:  0.585
Data Source:  STRINGDB
ALG2
Tbio
Family:  Enzyme
Novelty:  0.03804805
Score:  0.523
Data Source:  STRINGDB
PTGR2
Tbio
Family:  Enzyme
Novelty:  0.08766092
Score:  0.514
Data Source:  STRINGDB
DHRSX
Tdark
Family:  Enzyme
Novelty:  0.24132104
Score:  0.497
Data Source:  STRINGDB
OXSM
Tbio
Family:  Enzyme
Novelty:  0.00615894
Score:  0.496
Data Source:  STRINGDB
MGST3
Tbio
Family:  Enzyme
Novelty:  0.02891864
Score:  0.495
Data Source:  STRINGDB
GLOD4
Tbio
Family:  Enzyme
Novelty:  0.11482749
Score:  0.494
Data Source:  STRINGDB
COX18
Tbio
Novelty:  0.06288021
Score:  0.485
Data Source:  STRINGDB
RDH10
Tbio
Family:  Enzyme
Novelty:  0.03049914
Score:  0.483
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
1
1
82.9
telomere length
1
1
1
82.9
platelet count
2
2
2
75
platelet count
2
2
2
75
mean corpuscular volume
2
2
2
62
Items per page:
1 – 5 of 30
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
1
82.9
telomere length
1
82.9
platelet count
2
75
platelet count
2
75
mean corpuscular volume
2
62
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dehydrogenase/reductase 1
VGNC:12779
452816
Macaque
dehydrogenase/reductase 1
715933
Mouse
MGI:1196314
52585
Rat
RGD:1359172
290234
Dog
dehydrogenase/reductase 1 [Source:HGNC Symbol;Acc:HGNC:16445]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dehydrogenase/reductase 1
Macaque
dehydrogenase/reductase 1
Mouse
Rat
Dog
dehydrogenase/reductase 1 [Source:HGNC Symbol;Acc:HGNC:16445]
Publication Statistics
PubMed Score 4.00
PubMed score by year
PubTator Score 1.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title