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Tbio
DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

Protein Summary
Description
This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221403
  • ENSP00000221403
  • ENSG00000104808

Symbol
  • 2DD
  • 2DD
  • HUM2DD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
gene perturbation
0.59
cell type or tissue
0.56
cellular component
0.54
tissue sample
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.06   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.06   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
AKR1C1
Tchem
Family:  Enzyme
Novelty:  0.0043847
Score:  0.984
Data Source:  STRINGDB
AKR1B1
Tclin
Family:  Enzyme
Novelty:  0.00045769
Score:  0.96
Data Source:  STRINGDB
AKR1B10
Tchem
Family:  Enzyme
Novelty:  0.00533958
Score:  0.955
Data Source:  STRINGDB
EPHX1
Tchem
Family:  Enzyme
Novelty:  0.00220169
Score:  0.938
Data Source:  STRINGDB
AKR1C2
Tchem
Family:  Enzyme
Novelty:  0.00134228
Score:  0.924
Data Source:  STRINGDB
AKR1C4
Tchem
Family:  Enzyme
Novelty:  0.00925635
Score:  0.924
Data Source:  STRINGDB
AKR1C3
Tchem
Family:  Enzyme
Novelty:  0.00257785
Score:  0.862
Data Source:  STRINGDB
DHRS9
Tbio
Family:  Enzyme
Novelty:  0.00256743
Score:  0.804
Data Source:  STRINGDB
AKR1E2
Tbio
Family:  Enzyme
Novelty:  0.12903327
Score:  0.758
Data Source:  STRINGDB
GALK2
Tbio
Family:  Kinase
Novelty:  0.06382824
Score:  0.75
Data Source:  STRINGDB
Pathways (4)
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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Metabolic pathways
KEGG
Metabolism of xenobiotics by cytochrome P450
KEGG
Pentose and glucuronate interconversions
Name
Explore in Pharos
Explore in Source
Metabolic pathways
Metabolism of xenobiotics by cytochrome P450
Pentose and glucuronate interconversions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
5
93.3
testosterone measurement
8
6
7
6.3
90.4
reticulocyte measurement
3
5
6
87.7
blood protein measurement
2
2
2
87.1
reticulocyte count
6
4
12
86.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
5
93.3
testosterone measurement
7
6.3
90.4
reticulocyte measurement
6
87.7
blood protein measurement
2
87.1
reticulocyte count
12
86.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dihydrodiol dehydrogenase
VGNC:7691
456194
Macaque
dihydrodiol dehydrogenase
718930
Mouse
MGI:1919005
71755
Rat
RGD:1588686
691002
Dog
dihydrodiol dehydrogenase
VGNC:39929
403786
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dihydrodiol dehydrogenase
Macaque
dihydrodiol dehydrogenase
Mouse
Rat
Dog
dihydrodiol dehydrogenase
Publication Statistics
PubMed Score 355.06
PubMed score by year
PubTator Score 24.17
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title