Tbio DHDDS Dehydrodolichyl diphosphate synthase complex subunit DHDDS

Protein Summary

Description

With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:25066056, PubMed:28842490). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394). The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q86SQ9
• B7Z4B9
• B7ZB20
• D3DPK7
• D3DPK8
• D3DPK9
• E9KL43
• Q5T0A4
• Q8NE90
• Q9BTG5
• Q9BTK3
• Q9H905

Gene Name

• DHDDS

Ensembl ID

• ENST00000236342
• ENSP00000236342
• ENSG00000117682
• ENST00000360009
• ENSP00000353104
• ENST00000525682
• ENSP00000434984
• ENST00000526219
• ENSP00000434219

Symbol

• HDS
• DS
• CIT
• CPT
• HDS
• RP59
• hCIT
• DEDSM

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
kinase perturbation	0.88
histone modification site profile	0.85
transcription factor binding site profile	0.8
microRNA	0.74

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Dehydrodolichyl Diphosphate Synthase Complex Subunit Dhdds

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Dehydrodolichyl Diphosphate Synthase Complex Subunit Dhdds

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.04   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.04   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0