DHCR24
Delta(24)-sterol reductase
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.98 | ||
transcription factor perturbation | 0.91 | ||
disease perturbation | 0.9 | ||
molecular function | 0.88 | ||
interacting protein | 0.86 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cholesterol biosynthesis | ||||
Reactome | Cholesterol biosynthesis via desmosterol | ||||
Reactome | Cholesterol biosynthesis via lathosterol | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cholesterol biosynthesis | ||||
Cholesterol biosynthesis via desmosterol | ||||
Cholesterol biosynthesis via lathosterol | ||||
Metabolism | ||||
Metabolism of lipids | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.1 | 60.8 | |||||
1 | 1 | 0 | 1.1 | 48.5 | |||||
low density lipoprotein cholesterol measurement | 1 | 1 | 1 | 17.3 | |||||
total cholesterol measurement | 1 | 1 | 1 | 13.2 | |||||
apolipoprotein B measurement | 1 | 1 | 1 | 13.1 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.1 | 60.8 | |||||
0 | 1.1 | 48.5 | |||||
low density lipoprotein cholesterol measurement | 1 | 17.3 | |||||
total cholesterol measurement | 1 | 13.2 | |||||
apolipoprotein B measurement | 1 | 13.1 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | 24-dehydrocholesterol reductase | VGNC:8251 | 456879 | |||||
Macaque | 24-dehydrocholesterol reductase | 717022 | ||||||
Mouse | MGI:1922004 | 74754 | ||||||
Rat | RGD:1306529 | 298298 | ||||||
Dog | 24-dehydrocholesterol reductase | VGNC:39926 | 489573 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | 24-dehydrocholesterol reductase | |||||
Macaque | 24-dehydrocholesterol reductase | |||||
Mouse | ||||||
Rat | ||||||
Dog | 24-dehydrocholesterol reductase | |||||
PMID | Year | Title |
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