Tchem DHCR24 Delta(24)-sterol reductase

Protein Summary

Description

Catalyzes the reduction of the Delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis. This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15392
• B7Z817
• D3DQ51
• Q9HBA8

Gene Name

• DHCR24

Ensembl ID

• ENST00000371269
• ENSP00000360316
• ENSG00000116133
• ENST00000436604
• ENSP00000416585
• ENST00000649007
• ENSP00000497151

Symbol

• KIAA0018
• DCE
• SELADIN1
• Nbla03646
• seladin-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
transcription factor perturbation	0.91
disease perturbation	0.9
molecular function	0.88
interacting protein	0.86

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Delta(24)-sterol Reductase

DTO Classes

Protein / Enzyme / Oxidoreductase / Reductase / Delta(24)-sterol Reductase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 302.8   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 232   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 302.8   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1