Tchem DHCR24 Delta(24)-sterol reductase

Protein Summary

Description

Catalyzes the reduction of the Delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis. This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q15392
• B7Z817
• D3DQ51
• Q9HBA8

Gene Name

• DHCR24

Ensembl ID

• ENST00000371269
• ENSP00000360316
• ENSG00000116133
• ENST00000436604
• ENSP00000416585
• ENST00000649007
• ENSP00000497151

Symbol

• KIAA0018
• DCE
• SELADIN1
• Nbla03646
• seladin-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
transcription factor perturbation	0.91
disease perturbation	0.9
molecular function	0.88
interacting protein	0.86

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Delta(24)-sterol Reductase

DTO Classes

Protein / Enzyme / Oxidoreductase / Reductase / Delta(24)-sterol Reductase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.68   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 232   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.68   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

gilteritinib

DHCR24Tchem Enzyme

INHIBITOR pIC50 : 8.52

Active Ligands (12)

Explore Active Ligands

1 – 10 of 12

CHEMBL4164183

DHCR24Tchem Enzyme

pIC50 : 10

N,N-dimethyl-3beta-hydroxycholenamide

DHCR24Tchem Enzyme

pIC50 : 9.15

CHEMBL4174848

DHCR24Tchem Enzyme

pIC50 : 8.6

CHEMBL4170755

DHCR24Tchem Enzyme

pIC50 : 8.54

CHEMBL4164005

DHCR24Tchem Enzyme

pIC50 : 8.48

CHEMBL4167637

DHCR24Tchem Enzyme

pIC50 : 8.38

CHEMBL4159728

DHCR24Tchem Enzyme

pIC50 : 8.26

CHEMBL4164428

DHCR24Tchem Enzyme

pIC50 : 8.2

CHEMBL4167452

DHCR24Tchem Enzyme

pIC50 : 6.7

CHEMBL4172305

DHCR24Tchem Enzyme

pIC50 : 6.69

Protein-Protein Interactions (80)

Explore Interacting Targets

1 – 10 of 80

• See Interactions on String-DB

LUZP1

Tbio

Novelty:  0.14991475

p_int:  0.994616356

p_ni:  0.005335499

p_wrong:  0.000048145

Score:  0.303

Data Source:  BioPlex,STRINGDB

FUNDC2

Tbio

Novelty:  0.09695817

p_int:  0.991709533

p_ni:  0.006268804

p_wrong:  0.002021663

Score:  0.23

Data Source:  BioPlex,STRINGDB

ATP6V0D1

Tbio

Family:  Enzyme

Novelty:  0.05146108

p_int:  0.986859765

p_ni:  0.013140235

Data Source:  BioPlex

ERAP1

Tchem

Family:  Enzyme

Novelty:  0.00404539

p_int:  0.951371802

p_ni:  0.048628198

Score:  0.21

Data Source:  BioPlex,STRINGDB

ATP12A

Tchem

Family:  Transporter

Novelty:  0.00008793

p_int:  0.93231908

p_ni:  0.067680919

p_wrong:  1e-9

Score:  0.173

Data Source:  BioPlex,STRINGDB

ACTA2

Tbio

Novelty:  0.00199354

p_int:  0.903230736

p_ni:  0.096769264

Score:  0.16

Data Source:  BioPlex,STRINGDB

PLAC9

Tdark

Novelty:  0.23764669

p_int:  0.880025212

p_ni:  0.119974788

Data Source:  BioPlex

HRAS

Tchem

Family:  Enzyme

Novelty:  0.00008069

p_int:  0.815806808

p_ni:  0.184186567

p_wrong:  0.000006626

Score:  0.298

Data Source:  BioPlex,STRINGDB

DHCR7

Tchem

Family:  Enzyme

Novelty:  0.00358937

Score:  0.988

Data Source:  STRINGDB

LSS

Tchem

Family:  Enzyme

Novelty:  0.00735187

Score:  0.978

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (14)

Reactome (6)

KEGG (2)

PathwayCommons (4)

UniProt (1)

WikiPathways (1)

Cholesterol biosynthesis (R-HSA-191273)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cholesterol biosynthesis	25 targets	R-HSA-191273
Reactome	Cholesterol biosynthesis via desmosterol	4 targets	R-HSA-6807047
Reactome	Cholesterol biosynthesis via lathosterol	4 targets	R-HSA-6807062
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833

Name	Explore in Pharos	Explore in Source
Cholesterol biosynthesis	25 targets	R-HSA-191273
Cholesterol biosynthesis via desmosterol	4 targets	R-HSA-6807047
Cholesterol biosynthesis via lathosterol	4 targets	R-HSA-6807062
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (26)

Functions (6)

Components (7)

Processes (13)

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1 – 6 of 6

GO Term	Evidence	Assigned by
delta24-sterol reductase activity	Inferred from Experiment (EXP)	Reactome
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	Inferred from Direct Assay (IDA)	MGI
enzyme binding	Inferred from Physical Interaction (IPI)	UniProtKB
peptide antigen binding	Inferred from Physical Interaction (IPI)	UniProtKB
delta24(24-1) sterol reductase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
FAD binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (5)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
colorectal cancer	EFO_0005842	2	2	0	1.1	60.8
colorectal adenoma	EFO_0005406	1	1	0	1.1	48.5
low density lipoprotein cholesterol measurement	EFO_0004611	1	1	1		17.3
total cholesterol measurement	EFO_0004574	1	1	1		13.2
apolipoprotein B measurement	EFO_0004615	1	1	1		13.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
colorectal cancer	EFO_0005842	0	1.1	60.8
colorectal adenoma	EFO_0005406	0	1.1	48.5
low density lipoprotein cholesterol measurement	EFO_0004611	1		17.3
total cholesterol measurement	EFO_0004574	1		13.2
apolipoprotein B measurement	EFO_0004615	1		13.1

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cholesterol biosynthesis
Cholesterol metabolism
Complete proteome
Disease mutation
Endoplasmic reticulum
FAD
Flavoprotein
Golgi apparatus
Lipid biosynthesis

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein B measurement
colorectal adenoma
colorectal cancer
low density lipoprotein cholesterol measurement
total cholesterol measurement

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
integument phenotype
mortality/aging
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	24-dehydrocholesterol reductase	VGNC:8251	456879
Macaque	24-dehydrocholesterol reductase		717022
Mouse	24-dehydrocholesterol reductase	MGI:1922004	74754
Rat	24-dehydrocholesterol reductase	RGD:1306529	298298
Dog	24-dehydrocholesterol reductase	VGNC:39926	489573

Species	Name	OMA	EggNOG	Inparanoid
Chimp	24-dehydrocholesterol reductase
Macaque	24-dehydrocholesterol reductase
Mouse	24-dehydrocholesterol reductase
Rat	24-dehydrocholesterol reductase
Dog	24-dehydrocholesterol reductase

Publication Statistics

PubMed Score 243.68

PubMed score by year

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PubTator Score 178.22

PubTator score by year

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Related Publications

Text Mined References (58)

GeneRif Annotations (43)

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PMID	Year	Title