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Tchem
DHCR24
Delta(24)-sterol reductase

Protein Summary
Description
Catalyzes the reduction of the Delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis. This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371269
  • ENSP00000360316
  • ENSG00000116133
  • ENST00000436604
  • ENSP00000416585
  • ENST00000649007
  • ENSP00000497151

Symbol
  • KIAA0018
  • DCE
  • SELADIN1
  • Nbla03646
  • seladin-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
transcription factor perturbation
0.91
disease perturbation
0.9
molecular function
0.88
interacting protein
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.68   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 243.68   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (12)
CHEMBL4164183
Rendered image for CHEMBL4164183
CHEMBL4174848
Rendered image for CHEMBL4174848
CHEMBL4170755
Rendered image for CHEMBL4170755
CHEMBL4164005
Rendered image for CHEMBL4164005
CHEMBL4167637
Rendered image for CHEMBL4167637
CHEMBL4159728
Rendered image for CHEMBL4159728
CHEMBL4164428
Rendered image for CHEMBL4164428
CHEMBL4167452
Rendered image for CHEMBL4167452
CHEMBL4172305
Rendered image for CHEMBL4172305
Protein-Protein Interactions (80)
LUZP1
Tbio
Novelty:  0.14991475
p_int:  0.994616356
p_ni:  0.005335499
p_wrong:  0.000048145
Score:  0.303
Data Source:  BioPlex,STRINGDB
FUNDC2
Tbio
Novelty:  0.09695817
p_int:  0.991709533
p_ni:  0.006268804
p_wrong:  0.002021663
Score:  0.23
Data Source:  BioPlex,STRINGDB
ATP6V0D1
Tbio
Family:  Enzyme
Novelty:  0.05146108
p_int:  0.986859765
p_ni:  0.013140235
Data Source:  BioPlex
ERAP1
Tchem
Family:  Enzyme
Novelty:  0.00404539
p_int:  0.951371802
p_ni:  0.048628198
Score:  0.21
Data Source:  BioPlex,STRINGDB
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.93231908
p_ni:  0.067680919
p_wrong:  1e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.903230736
p_ni:  0.096769264
Score:  0.16
Data Source:  BioPlex,STRINGDB
PLAC9
Tdark
Novelty:  0.23764669
p_int:  0.880025212
p_ni:  0.119974788
Data Source:  BioPlex
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
p_int:  0.815806808
p_ni:  0.184186567
p_wrong:  0.000006626
Score:  0.298
Data Source:  BioPlex,STRINGDB
DHCR7
Tchem
Family:  Enzyme
Novelty:  0.00358937
Score:  0.988
Data Source:  STRINGDB
LSS
Tchem
Family:  Enzyme
Novelty:  0.00735187
Score:  0.978
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Cholesterol biosynthesis (R-HSA-191273)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cholesterol biosynthesis
Reactome
Cholesterol biosynthesis via desmosterol
Reactome
Cholesterol biosynthesis via lathosterol
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Cholesterol biosynthesis
Cholesterol biosynthesis via desmosterol
Cholesterol biosynthesis via lathosterol
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
60.8
1
1
0
1.1
48.5
low density lipoprotein cholesterol measurement
1
1
1
17.3
total cholesterol measurement
1
1
1
13.2
apolipoprotein B measurement
1
1
1
13.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
60.8
0
1.1
48.5
low density lipoprotein cholesterol measurement
1
17.3
total cholesterol measurement
1
13.2
apolipoprotein B measurement
1
13.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
24-dehydrocholesterol reductase
VGNC:8251
456879
Macaque
24-dehydrocholesterol reductase
717022
Mouse
MGI:1922004
74754
Rat
RGD:1306529
298298
Dog
24-dehydrocholesterol reductase
VGNC:39926
489573
Species
Name
OMA
EggNOG
Inparanoid
Chimp
24-dehydrocholesterol reductase
Macaque
24-dehydrocholesterol reductase
Mouse
Rat
Dog
24-dehydrocholesterol reductase
Publication Statistics
PubMed Score 243.68
PubMed score by year
PubTator Score 178.22
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title