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Tbio
DGUOK
Deoxyguanosine kinase, mitochondrial

Protein Summary
Description
Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents. In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this g ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264093
  • ENSP00000264093
  • ENSG00000114956
  • ENST00000348222
  • ENSP00000306964
  • ENST00000418996
  • ENSP00000408209
  • ENST00000629438
  • ENSP00000487122

Symbol
  • DGK
  • dGK
  • NCPH
  • PEOB4
  • MTDPS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
molecular function
0.91
transcription factor perturbation
0.84
transcription factor binding site profile
0.82
biological process
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.87   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.87   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (182)
DCK
Tchem
Family:  Kinase
Novelty:  0.00201831
p_int:  0.999999988
p_ni:  4e-9
p_wrong:  1e-8
Score:  0.305
Data Source:  BioPlex,STRINGDB
SYN1
Tbio
Novelty:  0.00093242
p_int:  0.999999249
p_ni:  7.5e-7
Data Source:  BioPlex
STX1B
Tbio
Novelty:  0.01171833
p_int:  0.999992292
p_ni:  0.000007694
p_wrong:  1.4e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
HIST1H2BL
Tdark
Novelty:  0.64500134
p_int:  0.999992218
p_ni:  0.000007772
p_wrong:  1e-8
Data Source:  BioPlex
L1CAM
Tbio
Novelty:  0.00307041
p_int:  0.999990528
p_ni:  0.000009422
p_wrong:  5e-8
Score:  0.154
Data Source:  BioPlex,STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
p_int:  0.999988204
p_ni:  0.000011592
p_wrong:  2.03e-7
Score:  0.197
Data Source:  BioPlex,STRINGDB
HPCA
Tbio
Novelty:  0.01360155
p_int:  0.999980359
p_ni:  0.00001964
p_wrong:  1e-9
Data Source:  BioPlex
SYN2
Tbio
Novelty:  0.00574709
p_int:  0.999974836
p_ni:  0.000025151
p_wrong:  1.3e-8
Data Source:  BioPlex
VSNL1
Tbio
Novelty:  0.01221371
p_int:  0.999946009
p_ni:  0.000053886
p_wrong:  1.05e-7
Data Source:  BioPlex
NAPB
Tdark
Novelty:  0.31464404
p_int:  0.999918549
p_ni:  0.000021884
p_wrong:  0.000059567
Data Source:  BioPlex
Nearest Tclin Targets (22)
Explore Nearest Tclin Targets
1 – 5 of 21
PDE6C
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
GUCY1A1
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
PDE3B
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
PDE10A
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
PDE5A
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Pathways (9)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleotide salvage
Reactome
Purine salvage
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleotide salvage
Purine salvage
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
2
2
89.7
2
2
0
1.3
79.5
eosinophil count
1
1
1
54.4
lymphocyte count
1
1
1
42.3
mitochondrial DNA measurement
1
1
1
28.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
2
89.7
0
1.3
79.5
eosinophil count
1
54.4
lymphocyte count
1
42.3
mitochondrial DNA measurement
1
28.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
deoxyguanosine kinase
VGNC:222
459328
Macaque
deoxyguanosine kinase
707554
Mouse
MGI:1351602
27369
Rat
RGD:1304799
297389
Dog
deoxyguanosine kinase
VGNC:39925
475791
Species
Name
OMA
EggNOG
Inparanoid
Chimp
deoxyguanosine kinase
Macaque
deoxyguanosine kinase
Mouse
Rat
Dog
deoxyguanosine kinase
Publication Statistics
PubMed Score 117.87
PubMed score by year
PubTator Score 63.41
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title