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Tchem
DGKZ
Diacylglycerol kinase zeta

Protein Summary
Description
Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity (PubMed:11257115). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Activates PIP5K1A activity via generation of phosphatidic acid (PubMed:15157668). The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318201
  • ENSP00000320340
  • ENSG00000149091
  • ENST00000343674
  • ENSP00000343065
  • ENST00000421244
  • ENSP00000391021
  • ENST00000454345
  • ENSP00000412178
  • ENST00000456247
  • ENSP00000395684
  • ENST00000527911
  • ENSP00000436291
  • ENST00000532868
  • ENSP00000436273

Symbol
  • DAGK6
  • DAGK5
  • DAGK6
  • DGK-ZETA
  • hDGKzeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
transcription factor
0.86
protein domain
0.85
transcription factor perturbation
0.74
metabolite
0.72


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.38   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.38   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0