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Tbio
DGKD
Diacylglycerol kinase delta

Protein Summary
Description
May function as signaling molecule. Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis. This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264057
  • ENSP00000264057
  • ENSG00000077044
  • ENST00000409813
  • ENSP00000386455
  • ENST00000628356
  • ENSP00000487220
  • ENSG00000280873
  • ENST00000628527
  • ENSP00000487423

Symbol
  • KIAA0145
  • dgkd-2
  • DGKdelta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
virus perturbation
0.99
molecular function
0.98
metabolite
0.85
cell type or tissue
0.78


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.88   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.88   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0