You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DGCR2
Integral membrane protein DGCR2/IDD

Protein Summary
Description
Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration. Deletions of the 22q11.2 have been associated with a wide range of developmental defects (notably DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome and isolated conotruncal cardiac defects) classified under the acronym CATCH 22. The DGCR2 gene encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263196
  • ENSP00000263196
  • ENSG00000070413
  • ENST00000537045
  • ENSP00000440062

Symbol
  • IDD
  • KIAA0163
  • IDD
  • LAN
  • DGS-C
  • SEZ-12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
disease perturbation
0.74
transcription factor perturbation
0.74
tissue sample
0.68
cell type or tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.42   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.42   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
ADAM33
Tchem
Family:  Enzyme
Novelty:  0.00584097
p_int:  0.917796548
p_ni:  0.082203452
Score:  0.199
Data Source:  BioPlex,STRINGDB
HIRA
Tbio
Novelty:  0.01362595
Score:  0.759
Data Source:  STRINGDB
ESS2
Tbio
Novelty:  0.00163665
Score:  0.754
Data Source:  STRINGDB
ZDHHC8
Tbio
Family:  Enzyme
Novelty:  0.03434357
Score:  0.679
Data Source:  STRINGDB
GP1BB
Tbio
Novelty:  0.01235173
Score:  0.671
Data Source:  STRINGDB
SLC25A1
Tbio
Family:  Transporter
Novelty:  0.00547533
Score:  0.656
Data Source:  STRINGDB
ADI1
Tbio
Family:  Enzyme
Novelty:  0.00908955
Score:  0.654
Data Source:  STRINGDB
TBX1
Tbio
Family:  TF
Novelty:  0.00154882
Score:  0.644
Data Source:  STRINGDB
DGCR6
Tbio
Novelty:  0.1511746
Score:  0.641
Data Source:  STRINGDB
DGCR6L
Tbio
Novelty:  0.11554203
Score:  0.641
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
22q11.2 Deletion Syndrome
WikiPathways
22q11.2 Deletion Syndrome
WikiPathways
22q11.2 Deletion Syndrome
Name
Explore in Pharos
Explore in Source
22q11.2 Deletion Syndrome
22q11.2 Deletion Syndrome
22q11.2 Deletion Syndrome
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
4
3
4
95.6
amino acid measurement
2
2
2
89.1
metabolite measurement
2
2
2
78
serum metabolite measurement
2
2
2
77.3
glomerular filtration rate
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
4
95.6
amino acid measurement
2
89.1
metabolite measurement
2
78
serum metabolite measurement
2
77.3
glomerular filtration rate
1
36.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DiGeorge syndrome critical region gene 2
458644
Macaque
DiGeorge syndrome critical region gene 2
100423715
Mouse
MGI:5141983
Rat
RGD:1310567
360742
Dog
DiGeorge syndrome critical region gene 2
486428
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DiGeorge syndrome critical region gene 2
Macaque
DiGeorge syndrome critical region gene 2
Mouse
Rat
Dog
DiGeorge syndrome critical region gene 2
Publication Statistics
PubMed Score 17.42
PubMed score by year
PubTator Score 46.84
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title