Tbio DEUP1 Deuterosome assembly protein 1

Protein Summary

Description

Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity).

Uniprot Accession IDs

• Q05D60
• E9PJR5
• Q8NEF1
• Q96LL7

Gene Name

• DEUP1

Ensembl ID

• ENST00000298050
• ENSP00000298050
• ENSG00000165325

Symbol

• CCDC67
• CCDC67

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Deuterosome Assembly Protein 1

DTO Classes

Protein / Cellular Structure / Deuterosome Assembly Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.18   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 83   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.18   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0