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Tbio
DEUP1
Deuterosome assembly protein 1

Protein Summary
Description
Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298050
  • ENSP00000298050
  • ENSG00000165325

Symbol
  • CCDC67
  • CCDC67
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.59   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.59   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
HIP1
Tbio
Novelty:  0.03790722
p_int:  0.999999148
p_ni:  8.52e-7
Score:  0.237
Data Source:  BioPlex,STRINGDB
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.999999013
p_ni:  9.7e-7
p_wrong:  1.7e-8
Score:  0.227
Data Source:  BioPlex,STRINGDB
MAFG
Tbio
Family:  TF
Novelty:  0.01605125
p_int:  0.999998791
p_ni:  0.000001
p_wrong:  2.09e-7
Score:  0.237
Data Source:  BioPlex,STRINGDB
ANXA13
Tbio
Novelty:  0.01534307
p_int:  0.999980259
p_ni:  0.000004738
p_wrong:  0.000015003
Score:  0.188
Data Source:  BioPlex,STRINGDB
TRAF6
Tbio
Novelty:  0.00109366
p_int:  0.999972642
p_ni:  0.000027348
p_wrong:  1e-8
Score:  0.217
Data Source:  BioPlex,STRINGDB
SPAG5
Tbio
Novelty:  0.02392116
p_int:  0.999965819
p_ni:  0.000034181
Score:  0.16
Data Source:  BioPlex,STRINGDB
GOLGA3
Tbio
Novelty:  0.03018438
p_int:  0.999806958
p_ni:  0.000193042
Score:  0.186
Data Source:  BioPlex,STRINGDB
DGKH
Tbio
Family:  Kinase
Novelty:  0.01576406
p_int:  0.998446417
p_ni:  0.000012693
p_wrong:  0.00154089
Score:  0.243
Data Source:  BioPlex,STRINGDB
FAAP100
Tdark
Novelty:  0.1698504
p_int:  0.997488524
p_ni:  0.002340772
p_wrong:  0.000170704
Data Source:  BioPlex
KNSTRN
Tbio
Novelty:  0.05283444
p_int:  0.993146012
p_ni:  0.006853781
p_wrong:  2.06e-7
Score:  0.177
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
1
2
42.3
body height
1
1
1
24.5
1
1
0
1
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
42.3
body height
1
24.5
0
1
5.2
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
deuterosome assembly protein 1
VGNC:3170
736887
Macaque
deuterosome assembly protein 1
695855
Mouse
MGI:2443026
234964
Rat
RGD:1306632
315438
Dog
deuterosome assembly protein 1
VGNC:39908
476771
Species
Name
OMA
EggNOG
Inparanoid
Chimp
deuterosome assembly protein 1
Macaque
deuterosome assembly protein 1
Mouse
Rat
Dog
deuterosome assembly protein 1
Publication Statistics
PubMed Score 10.59
PubMed score by year
PubTator Score 3.33
PubTator score by year
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Related Publications
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PMID
Year
Title