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Tbio
DET1
DET1 homolog

Protein Summary
Description
Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268148
  • ENSP00000268148
  • ENSG00000140543
  • ENST00000444300
  • ENSP00000408994
  • ENST00000564406
  • ENSP00000456340
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
histone modification site profile
0.85
transcription factor binding site profile
0.83
kinase perturbation
0.71
cell line
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.95   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.95   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (325)
COP1
Tbio
Family:  Enzyme
Novelty:  0.10908534
p_int:  0.999999998
p_ni:  2e-9
Score:  0.979
Data Source:  BioPlex,STRINGDB
TRIB2
Tbio
Family:  Kinase
Novelty:  0.02240668
p_int:  0.999999846
p_ni:  1.53e-7
p_wrong:  1e-9
Score:  0.802
Data Source:  BioPlex,STRINGDB
TRIB1
Tbio
Family:  Kinase
Novelty:  0.01587891
p_int:  0.99999966
p_ni:  3.4e-7
Score:  0.847
Data Source:  BioPlex,STRINGDB
UBE2E2
Tbio
Novelty:  0.02752227
p_int:  0.999999252
p_ni:  7.09e-7
p_wrong:  3.9e-8
Score:  0.945
Data Source:  BioPlex,STRINGDB
ETV5
Tbio
Family:  TF
Novelty:  0.00052506
p_int:  0.999997975
p_ni:  0.000002025
Score:  0.865
Data Source:  BioPlex,STRINGDB
FOS
Tbio
Family:  TF
Novelty:  0.00006103
p_int:  0.999959433
p_ni:  0.000040564
p_wrong:  3e-9
Score:  0.873
Data Source:  BioPlex,STRINGDB
UBE2E3
Tbio
Novelty:  0.03477232
p_int:  0.999880764
p_ni:  0.000119232
p_wrong:  5e-9
Score:  0.952
Data Source:  BioPlex,STRINGDB
ETV1
Tbio
Family:  TF
Novelty:  0.0055085
p_int:  0.999845756
p_ni:  0.000154231
p_wrong:  1.2e-8
Score:  0.874
Data Source:  BioPlex,STRINGDB
CUL4A
Tchem
Novelty:  0.00917788
p_int:  0.999791477
p_ni:  0.000208523
Score:  0.993
Data Source:  BioPlex,STRINGDB
STK40
Tbio
Family:  Kinase
Novelty:  0.10461675
p_int:  0.999774762
p_ni:  0.000225236
p_wrong:  2e-9
Score:  0.817
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
puberty onset measurement
1
1
1
69.2
age at menarche
1
1
1
53.7
testosterone measurement
2
2
2
52.3
BMI-adjusted hip circumference
2
2
2
42.1
hormone measurement
1
1
1
7.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
puberty onset measurement
1
69.2
age at menarche
1
53.7
testosterone measurement
2
52.3
BMI-adjusted hip circumference
2
42.1
hormone measurement
1
7.5
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
de-etiolated homolog 1 (Arabidopsis)
744350
Macaque
de-etiolated homolog 1 (Arabidopsis)
697994
Mouse
MGI:1923625
76375
Rat
RGD:1309793
308775
Dog
DET1, COP1 ubiquitin ligase partner
VGNC:49598
479036
Species
Name
OMA
EggNOG
Inparanoid
Chimp
de-etiolated homolog 1 (Arabidopsis)
Macaque
de-etiolated homolog 1 (Arabidopsis)
Mouse
Rat
Dog
DET1, COP1 ubiquitin ligase partner
Publication Statistics
PubMed Score 88.95
PubMed score by year
PubTator Score 11.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title