Protein Summary
Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.
- ENST00000268148
- ENSP00000268148
- ENSG00000140543
- ENST00000444300
- ENSP00000408994
- ENST00000564406
- ENSP00000456340
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 0.98 | ||
histone modification site profile | 0.85 | ||
transcription factor binding site profile | 0.83 | ||
kinase perturbation | 0.71 | ||
cell line | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 88.95 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 60 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 88.95 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 60 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (325)
COP1
Family: Enzyme
Novelty: 0.10908534
p_int: 0.999999998
p_ni: 2e-9
Score: 0.979
Data Source: BioPlex,STRINGDB
TRIB2
Family: Kinase
Novelty: 0.02240668
p_int: 0.999999846
p_ni: 1.53e-7
p_wrong: 1e-9
Score: 0.802
Data Source: BioPlex,STRINGDB
TRIB1
Family: Kinase
Novelty: 0.01587891
p_int: 0.99999966
p_ni: 3.4e-7
Score: 0.847
Data Source: BioPlex,STRINGDB
UBE2E2
Novelty: 0.02752227
p_int: 0.999999252
p_ni: 7.09e-7
p_wrong: 3.9e-8
Score: 0.945
Data Source: BioPlex,STRINGDB
ETV5
Family: TF
Novelty: 0.00052506
p_int: 0.999997975
p_ni: 0.000002025
Score: 0.865
Data Source: BioPlex,STRINGDB
FOS
Family: TF
Novelty: 0.00006103
p_int: 0.999959433
p_ni: 0.000040564
p_wrong: 3e-9
Score: 0.873
Data Source: BioPlex,STRINGDB
UBE2E3
Novelty: 0.03477232
p_int: 0.999880764
p_ni: 0.000119232
p_wrong: 5e-9
Score: 0.952
Data Source: BioPlex,STRINGDB
ETV1
Family: TF
Novelty: 0.0055085
p_int: 0.999845756
p_ni: 0.000154231
p_wrong: 1.2e-8
Score: 0.874
Data Source: BioPlex,STRINGDB
CUL4A
Novelty: 0.00917788
p_int: 0.999791477
p_ni: 0.000208523
Score: 0.993
Data Source: BioPlex,STRINGDB
STK40
Family: Kinase
Novelty: 0.10461675
p_int: 0.999774762
p_ni: 0.000225236
p_wrong: 2e-9
Score: 0.817
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Class I MHC mediated antigen processing & presentation | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (3)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
puberty onset measurement | 1 | 1 | 1 | 69.2 | |||||
age at menarche | 1 | 1 | 1 | 53.7 | |||||
testosterone measurement | 2 | 2 | 2 | 52.3 | |||||
BMI-adjusted hip circumference | 2 | 2 | 2 | 42.1 | |||||
hormone measurement | 1 | 1 | 1 | 7.5 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
puberty onset measurement | 1 | 69.2 | |||||
age at menarche | 1 | 53.7 | |||||
testosterone measurement | 2 | 52.3 | |||||
BMI-adjusted hip circumference | 2 | 42.1 | |||||
hormone measurement | 1 | 7.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | de-etiolated homolog 1 (Arabidopsis) | 744350 | ||||||
Macaque | de-etiolated homolog 1 (Arabidopsis) | 697994 | ||||||
Mouse | MGI:1923625 | 76375 | ||||||
Rat | RGD:1309793 | 308775 | ||||||
Dog | DET1, COP1 ubiquitin ligase partner | VGNC:49598 | 479036 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | de-etiolated homolog 1 (Arabidopsis) | |||||
Macaque | de-etiolated homolog 1 (Arabidopsis) | |||||
Mouse | ||||||
Rat | ||||||
Dog | DET1, COP1 ubiquitin ligase partner | |||||
Publication Statistics
PubMed Score 88.95
PubMed score by year
PubTator Score 11.60
PubTator score by year
Related Publications
Text Mined References (8)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
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