Tbio DET1 DET1 homolog

Protein Summary

Description

Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.

Uniprot Accession IDs

• Q7L5Y6
• B3KNN6
• Q2VPC0
• Q9NWD5

Gene Name

• DET1

Ensembl ID

• ENST00000268148
• ENSP00000268148
• ENSG00000140543
• ENST00000444300
• ENSP00000408994
• ENST00000564406
• ENSP00000456340

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
histone modification site profile	0.85
transcription factor binding site profile	0.83
kinase perturbation	0.71
cell line	0.58

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / Det1 Homolog

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / Det1 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.95   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 60   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.95   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (325)

Explore Interacting Targets

1 – 10 of 325

• See Interactions on String-DB

COP1

Tbio

Family:  Enzyme

Novelty:  0.10908534

p_int:  0.999999998

p_ni:  2e-9

Score:  0.979

Data Source:  BioPlex,STRINGDB

TRIB2

Tbio

Family:  Kinase

Novelty:  0.02240668

p_int:  0.999999846

p_ni:  1.53e-7

p_wrong:  1e-9

Score:  0.802

Data Source:  BioPlex,STRINGDB

TRIB1

Tbio

Family:  Kinase

Novelty:  0.01587891

p_int:  0.99999966

p_ni:  3.4e-7

Score:  0.847

Data Source:  BioPlex,STRINGDB

UBE2E2

Tbio

Novelty:  0.02752227

p_int:  0.999999252

p_ni:  7.09e-7

p_wrong:  3.9e-8

Score:  0.945

Data Source:  BioPlex,STRINGDB

ETV5

Tbio

Family:  TF

Novelty:  0.00052506

p_int:  0.999997975

p_ni:  0.000002025

Score:  0.865

Data Source:  BioPlex,STRINGDB

FOS

Tbio

Family:  TF

Novelty:  0.00006103

p_int:  0.999959433

p_ni:  0.000040564

p_wrong:  3e-9

Score:  0.873

Data Source:  BioPlex,STRINGDB

UBE2E3

Tbio

Novelty:  0.03477232

p_int:  0.999880764

p_ni:  0.000119232

p_wrong:  5e-9

Score:  0.952

Data Source:  BioPlex,STRINGDB

ETV1

Tbio

Family:  TF

Novelty:  0.0055085

p_int:  0.999845756

p_ni:  0.000154231

p_wrong:  1.2e-8

Score:  0.874

Data Source:  BioPlex,STRINGDB

CUL4A

Tchem

Novelty:  0.00917788

p_int:  0.999791477

p_ni:  0.000208523

Score:  0.993

Data Source:  BioPlex,STRINGDB

STK40

Tbio

Family:  Kinase

Novelty:  0.10461675

p_int:  0.999774762

p_ni:  0.000225236

p_wrong:  2e-9

Score:  0.817

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (4)

KEGG (1)

Adaptive Immune System (R-HSA-1280218)

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5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Antigen processing: Ubiquitination & Proteasome degradation	307 targets	R-HSA-983168
Reactome	Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Antigen processing: Ubiquitination & Proteasome degradation	307 targets	R-HSA-983168
Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169
Immune System	2246 targets	R-HSA-168256

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (3)

Components (3)

Processes (3)

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1 – 3 of 3

GO Term	Evidence	Assigned by
protein-containing complex binding	Inferred from Direct Assay (IDA)	UniProtKB
protein binding, bridging involved in substrate recognition for ubiquitination	Inferred from Physical Interaction (IPI)	UniProtKB
ubiquitin protein ligase binding	Inferred from Mutant Phenotype (IMP)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
puberty onset measurement	EFO_0005677	1	1	1		69.2
age at menarche	EFO_0004703	1	1	1		53.7
testosterone measurement	EFO_0004908	2	2	2		52.3
BMI-adjusted hip circumference	EFO_0008039	2	2	2		42.1
hormone measurement	EFO_0004730	1	1	1		7.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
puberty onset measurement	EFO_0005677	1		69.2
age at menarche	EFO_0004703	1		53.7
testosterone measurement	EFO_0004908	2		52.3
BMI-adjusted hip circumference	EFO_0008039	2		42.1
hormone measurement	EFO_0004730	1		7.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Nucleus
Reference proteome
Ubl conjugation pathway

GWAS Trait Find Similar Targets

No Header	No Header
age at menarche
BMI-adjusted hip circumference
hormone measurement
IGF-1 measurement
major depressive disorder
puberty onset measurement
testosterone measurement
unipolar depression

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	de-etiolated homolog 1 (Arabidopsis)		744350
Macaque	de-etiolated homolog 1 (Arabidopsis)		697994
Mouse	de-etiolated homolog 1 (Arabidopsis)	MGI:1923625	76375
Rat	DET1, COP1 ubiquitin ligase partner	RGD:1309793	308775
Dog	DET1, COP1 ubiquitin ligase partner	VGNC:49598	479036

Species	Name	OMA	EggNOG	Inparanoid
Chimp	de-etiolated homolog 1 (Arabidopsis)
Macaque	de-etiolated homolog 1 (Arabidopsis)
Mouse	de-etiolated homolog 1 (Arabidopsis)
Rat	DET1, COP1 ubiquitin ligase partner
Dog	DET1, COP1 ubiquitin ligase partner

Publication Statistics

PubMed Score 88.95

PubMed score by year

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PubTator Score 11.60

PubTator score by year

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Related Publications

Text Mined References (8)

GeneRif Annotations (2)

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10

0 of 0

PMID	Year	Title