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Tbio
DES
Desmin

Protein Summary
Description
Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Pl ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
cellular component
0.89
hub protein
0.88
kinase
0.77
chemical
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.63   (req: < 5)
Gene RIFs: 83   (req: <= 3)
Antibodies: 1351   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.63   (req: >= 5)
Gene RIFs: 83   (req: > 3)
Antibodies: 1351   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (79)
SYNC
Tbio
Novelty:  0.04605223
p_int:  0.999999942
p_ni:  9e-9
p_wrong:  4.8e-8
Score:  0.718
Data Source:  BioPlex,STRINGDB
NEFM
Tbio
Novelty:  0.00239134
p_int:  0.99999986
p_ni:  2e-8
p_wrong:  1.2e-7
Score:  0.829
Data Source:  BioPlex,STRINGDB
GFAP
Tbio
Novelty:  0.00020932
p_int:  0.999999619
p_ni:  3.8e-7
p_wrong:  1e-9
Score:  0.827
Data Source:  BioPlex,STRINGDB
VIM
Tbio
Novelty:  0.00030317
p_int:  0.999999562
p_ni:  2e-9
p_wrong:  4.36e-7
Score:  0.987
Data Source:  BioPlex,STRINGDB
PSMD3
Tbio
Family:  Enzyme
Novelty:  0.03106272
p_int:  0.999996874
p_ni:  0.000003126
Data Source:  BioPlex
RSPH6A
Tdark
Novelty:  0.03734897
p_int:  0.999988635
p_ni:  0.000011364
p_wrong:  1e-9
Data Source:  BioPlex
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.999966973
p_ni:  0.000033025
p_wrong:  2e-9
Data Source:  BioPlex
MECOM
Tbio
Family:  TF; Epigenetic
Novelty:  0.00500501
p_int:  0.999944429
p_ni:  0.000054455
p_wrong:  0.000001116
Data Source:  BioPlex
SPATA22
Tbio
Novelty:  0.18061361
p_int:  0.999842324
p_ni:  0.000013573
p_wrong:  0.000144104
Score:  0.416
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999315197
p_ni:  0.000135165
p_wrong:  0.000549637
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (39)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
3
4
88.8
creatinine measurement
1
2
2
85.6
electrocardiography
1
1
82
75.9
soluble triggering receptor expressed on myeloid cells 2 measurement
1
1
0
15744.7
53.3
vital capacity
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
88.8
creatinine measurement
2
85.6
electrocardiography
82
75.9
soluble triggering receptor expressed on myeloid cells 2 measurement
0
15744.7
53.3
vital capacity
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
desmin
VGNC:162
470657
Macaque
desmin
703300
Mouse
MGI:94885
13346
Rat
RGD:620686
64362
Dog
desmin
VGNC:39905
497091
Species
Name
OMA
EggNOG
Inparanoid
Chimp
desmin
Macaque
desmin
Mouse
Rat
Dog
desmin
Publication Statistics
PubMed Score 156.63
PubMed score by year
PubTator Score 2520.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title