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Tbio
DEPDC1B
DEP domain-containing protein 1B

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265036
  • ENSP00000265036
  • ENSG00000035499
  • ENST00000453022
  • ENSP00000389101

Symbol
  • XTP8
  • XTP1
  • BRCC3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.94
histone modification site profile
0.89
gene perturbation
0.78
protein domain
0.58
cell line
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.66   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.66   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (139)
IFI30
Tbio
Family:  Enzyme
Novelty:  0.00939681
p_int:  0.999999875
p_ni:  4.3e-8
p_wrong:  8.1e-8
Score:  0.303
Data Source:  BioPlex,STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.918
Data Source:  STRINGDB
RHOQ
Tbio
Family:  Enzyme
Novelty:  0.00562425
Score:  0.913
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.911
Data Source:  STRINGDB
RHOJ
Tbio
Family:  Enzyme
Novelty:  0.01217051
Score:  0.91
Data Source:  STRINGDB
RAC2
Tbio
Family:  Enzyme
Novelty:  0.00116234
Score:  0.905
Data Source:  STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
Score:  0.904
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.904
Data Source:  STRINGDB
RHOD
Tbio
Family:  Enzyme
Novelty:  0.0029764
Score:  0.903
Data Source:  STRINGDB
RHOH
Tbio
Family:  Enzyme
Novelty:  0.00882842
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
3
92.2
household income
2
6
6
90.9
mean platelet volume
2
2
2
89.1
intelligence
1
2
2
54.2
age at first sexual intercourse measurement
1
1
1
8.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
92.2
household income
6
90.9
mean platelet volume
2
89.1
intelligence
2
54.2
age at first sexual intercourse measurement
1
8.3
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEP domain containing 1B
VGNC:3966
461858
Macaque
DEP domain containing 1B
709670
Mouse
MGI:2145425
218581
Rat
RGD:1305799
310074
Dog
DEP domain containing 1B
VGNC:39897
608968
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEP domain containing 1B
Macaque
DEP domain containing 1B
Mouse
Rat
Dog
DEP domain containing 1B
Publication Statistics
PubMed Score 23.66
PubMed score by year
PubTator Score 4.80
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title