You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DEPDC1
DEP domain-containing protein 1A

Protein Summary
Description
May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370966
  • ENSP00000360005
  • ENSG00000024526
  • ENST00000456315
  • ENSP00000412292

Symbol
  • DEPDC1A
  • DEP.8
  • SDP35
  • DEPDC1A
  • DEPDC1-V2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
gene perturbation
0.85
microRNA
0.77
small molecule perturbation
0.73
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.06   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.06   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (154)
FAM234B
Tdark
Novelty:  1.53957047
p_int:  0.999997972
p_ni:  0.000002027
p_wrong:  1e-9
Data Source:  BioPlex
PDGFRB
Tclin
Family:  Kinase
Novelty:  0.00074896
p_int:  0.999995785
p_ni:  0.000004214
p_wrong:  1e-9
Data Source:  BioPlex
VSIG1
Tbio
Novelty:  0.15442611
p_int:  0.999810642
p_ni:  0.000183577
p_wrong:  0.000005781
Data Source:  BioPlex
IL27RA
Tbio
Novelty:  0.01348051
p_int:  0.997096129
p_ni:  0.002758247
p_wrong:  0.000145624
Data Source:  BioPlex
LRFN4
Tbio
Novelty:  0.12511571
p_int:  0.99685944
p_ni:  0.002998754
p_wrong:  0.000141806
Data Source:  BioPlex
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.996359681
p_ni:  0.003640316
p_wrong:  2e-9
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.995723148
p_ni:  0.002850305
p_wrong:  0.001426546
Data Source:  BioPlex
CD70
Tbio
Novelty:  0.00420393
p_int:  0.991148911
p_ni:  0.008736909
p_wrong:  0.00011418
Data Source:  BioPlex
SIGLECL1
Tdark
p_int:  0.991148911
p_ni:  0.008736909
p_wrong:  0.00011418
Data Source:  BioPlex
ICK
Tchem
Family:  Kinase
Novelty:  0.00810476
p_int:  0.990925844
p_ni:  0.004496295
p_wrong:  0.004577861
Score:  0.175
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
3
2
3
73.8
facial morphology measurement
1
1
2
26.6
testosterone measurement
1
1
1
4.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
3
73.8
facial morphology measurement
2
26.6
testosterone measurement
1
4.9
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEP domain containing 1
VGNC:10597
456933
Macaque
DEP domain containing 1
701888
Mouse
MGI:1923381
76131
Rat
RGD:1306987
295538
Dog
DEP domain containing 1
VGNC:39896
479992
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEP domain containing 1
Macaque
DEP domain containing 1
Mouse
Rat
Dog
DEP domain containing 1
Publication Statistics
PubMed Score 33.06
PubMed score by year
PubTator Score 13.93
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title