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Tbio
DEPDC1
DEP domain-containing protein 1A

Protein Summary
Description
May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370966
  • ENSP00000360005
  • ENSG00000024526
  • ENST00000456315
  • ENSP00000412292

Symbol
  • DEPDC1A
  • DEP.8
  • SDP35
  • DEPDC1A
  • DEPDC1-V2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
gene perturbation
0.85
microRNA
0.77
small molecule perturbation
0.73
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.29   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.29   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0