Tbio DEPDC1 DEP domain-containing protein 1A

Protein Summary

Description

May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.

Uniprot Accession IDs

• Q5TB30
• A8QXE0
• A8QXE1
• Q05DU3
• Q5TB28
• Q9H9I3
• Q9NX21
• Q9NXZ0

Gene Name

• DEPDC1

Ensembl ID

• ENST00000370966
• ENSP00000360005
• ENSG00000024526
• ENST00000456315
• ENSP00000412292

Symbol

• DEPDC1A
• DEP.8
• SDP35
• DEPDC1A
• DEPDC1-V2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.86
gene perturbation	0.85
microRNA	0.77
small molecule perturbation	0.73
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dep Domain-containing Protein 1a

DTO Classes

Protein / Nucleic Acid Binding / Dep Domain-containing Protein 1a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.29   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 139   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.29   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0