Tbio DENND6A Protein DENND6A

Protein Summary

Description

Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes.

Uniprot Accession IDs

• Q8IWF6
• Q7Z5T4
• Q8N235
• Q8TEG8

Gene Name

• DENND6A

Ensembl ID

• ENST00000311128
• ENSP00000311401
• ENSG00000174839

Symbol

• FAM116A
• AFI1A
• FAM116A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.74
tissue sample	0.67
microRNA	0.66
histone modification site profile	0.65
virus perturbation	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.49   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 50   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.49   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0