Tbio DENND2D DENN domain-containing protein 2D

Protein Summary

Description

Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Uniprot Accession IDs

• Q9H6A0
• Q5T5V6
• Q9BSU0

Gene Name

• DENND2D

Ensembl ID

• ENST00000357640
• ENSP00000350266
• ENSG00000162777
• ENST00000369752
• ENSP00000358767

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.82
virus perturbation	0.68
PubMedID	0.66
tissue sample	0.65
transcription factor perturbation	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.02   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.02   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0