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Tbio
DENND2D
DENN domain-containing protein 2D

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357640
  • ENSP00000350266
  • ENSG00000162777
  • ENST00000369752
  • ENSP00000358767
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.82
virus perturbation
0.68
PubMedID
0.66
tissue sample
0.65
transcription factor perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.41   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.41   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
RTF1
Tbio
Family:  Enzyme
Novelty:  0.02255644
p_int:  0.999998859
p_ni:  0.000001141
Score:  0.214
Data Source:  BioPlex,STRINGDB
FBXL19
Tbio
Novelty:  0.07526966
p_int:  0.99998952
p_ni:  0.00001045
p_wrong:  3e-8
Score:  0.217
Data Source:  BioPlex,STRINGDB
ELL
Tbio
Family:  Enzyme
Novelty:  0.00424352
p_int:  0.999831837
p_ni:  0.000168161
p_wrong:  1e-9
Score:  0.538
Data Source:  BioPlex,STRINGDB
NOLC1
Tbio
Novelty:  0.01922261
p_int:  0.999769286
p_ni:  0.000230714
Score:  0.187
Data Source:  BioPlex,STRINGDB
MLLT3
Tchem
Novelty:  0.00361056
p_int:  0.998678245
p_ni:  0.00132155
p_wrong:  2.05e-7
Data Source:  BioPlex
GRPEL1
Tbio
Novelty:  0.00185346
p_int:  0.998536662
p_ni:  0.001463338
Score:  0.524
Data Source:  BioPlex,STRINGDB
PNN
Tbio
Novelty:  0.01395394
p_int:  0.990572084
p_ni:  0.009427916
Data Source:  BioPlex
CWC22
Tbio
Novelty:  0.027689
p_int:  0.988894401
p_ni:  0.011105599
Score:  0.159
Data Source:  BioPlex,STRINGDB
C1orf52
Tdark
Novelty:  0.81942337
p_int:  0.98873053
p_ni:  0.011269433
p_wrong:  3.7e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
AFF4
Tbio
Family:  TF
Novelty:  0.02113896
p_int:  0.987591654
p_ni:  0.01238971
p_wrong:  0.000018637
Score:  0.499
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
4
95.9
serum gamma-glutamyl transferase measurement
3
2
2
4.3
84.7
neutrophil count
2
1
2
73
FEV/FEC ratio
1
1
1
72.9
neutrophil percentage of leukocytes
1
1
1
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
95.9
serum gamma-glutamyl transferase measurement
2
4.3
84.7
neutrophil count
2
73
FEV/FEC ratio
1
72.9
neutrophil percentage of leukocytes
1
70.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DENN domain containing 2D
VGNC:1228
469797
Mouse
MGI:2181193
72121
Rat
RGD:1305120
310772
Dog
DENN domain containing 2D
VGNC:39888
490105
Horse
DENN domain containing 2D
VGNC:17122
100058822
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DENN domain containing 2D
Mouse
Rat
Dog
DENN domain containing 2D
Horse
DENN domain containing 2D
Publication Statistics
PubMed Score 7.41
PubMed score by year
PubTator Score 8.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title