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Tbio
DELE1
DAP3-binding cell death enhancer 1

Protein Summary
Description
Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000194118
  • ENSP00000194118
  • ENSG00000081791
  • ENST00000432126
  • ENSP00000396225

Symbol
  • DELE
  • KIAA0141
  • DELE
  • KIAA0141
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
transcription factor perturbation
0.96
histone modification site profile
0.87
microRNA
0.73
cell type or tissue
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.33   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.33   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
EIF2AK1
Tchem
Family:  Kinase
Novelty:  0.01207075
p_int:  0.999997879
p_ni:  7e-8
p_wrong:  0.000002051
Score:  0.547
Data Source:  BioPlex,STRINGDB
BRAF
Tclin
Family:  Kinase
Novelty:  0.00253795
p_int:  0.999942984
p_ni:  0.000004487
p_wrong:  0.000052529
Score:  0.28
Data Source:  BioPlex,STRINGDB
TOR1A
Tbio
Novelty:  0.00056274
Score:  0.711
Data Source:  STRINGDB
ERLEC1
Tbio
Novelty:  0.01243855
Score:  0.675
Data Source:  STRINGDB
OS9
Tbio
Novelty:  0.01490339
Score:  0.675
Data Source:  STRINGDB
ENO2
Tbio
Family:  Enzyme
Novelty:  0.00016748
Score:  0.654
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.643
Data Source:  STRINGDB
LMNA
Tbio
Novelty:  0.00046972
Score:  0.628
Data Source:  STRINGDB
CLPB
Tbio
Family:  Enzyme
Novelty:  0.00209789
Score:  0.601
Data Source:  STRINGDB
TMEM9
Tbio
Novelty:  0.06916197
Score:  0.58
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
1
1
73.9
lymphocyte percentage of leukocytes
1
1
1
67.9
mean platelet volume
1
1
1
54.4
insomnia measurement
1
1
0
1
44.2
eosinophil count
1
1
1
8.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
1
73.9
lymphocyte percentage of leukocytes
1
67.9
mean platelet volume
1
54.4
insomnia measurement
0
1
44.2
eosinophil count
1
8.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DAP3 binding cell death enhancer 1
VGNC:4059
462153
Macaque
KIAA0141 ortholog
702802
Mouse
MGI:1914089
66839
Rat
RGD:735029
307480
Dog
DAP3 binding cell death enhancer 1
VGNC:53268
487190
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DAP3 binding cell death enhancer 1
Macaque
KIAA0141 ortholog
Mouse
Rat
Dog
DAP3 binding cell death enhancer 1
Publication Statistics
PubMed Score 10.33
PubMed score by year
PubTator Score 10.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title