Protein Summary
Involved in chromatin organization. This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
- ENST00000244776
- ENSP00000244776
- ENSG00000124795
- ENST00000397239
- ENSP00000380414
- D6S231E
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 1 | ||
kinase perturbation | 0.88 | ||
transcription factor binding site profile | 0.81 | ||
microRNA | 0.75 | ||
disease perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 308.23 (req: < 5)
Gene RIFs: 84 (req: <= 3)
Antibodies: 227 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 308.23 (req: >= 5)
Gene RIFs: 84 (req: > 3)
Antibodies: 227 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (188)
Nearest Tclin Targets
Pathways (9)
Reactome (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | B-WICH complex positively regulates rRNA expression | ||||
Reactome | Developmental Biology | ||||
Reactome | Epigenetic regulation of gene expression | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
B-WICH complex positively regulates rRNA expression | ||||
Developmental Biology | ||||
Epigenetic regulation of gene expression | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (3)
Components (3)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
response to mercaptopurine | 1 | 1 | 0 | 7.7 | 85.5 | ||||
thiopurine methyltransferase activity measurement | 1 | 1 | 0 | 7.7 | 85.5 | ||||
2 | 1 | 0 | 1.1 | 77 | |||||
1 | 1 | 0 | 5.6 | 21.5 | |||||
age at onset | 1 | 1 | 0 | 5.6 | 21.5 | ||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
response to mercaptopurine | 0 | 7.7 | 85.5 | ||||
thiopurine methyltransferase activity measurement | 0 | 7.7 | 85.5 | ||||
0 | 1.1 | 77 | |||||
0 | 5.6 | 21.5 | |||||
age at onset | 0 | 5.6 | 21.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | DEK proto-oncogene | VGNC:10022 | 462460 | |||||
Mouse | MGI:1926209 | 110052 | ||||||
Rat | RGD:1303246 | 306817 | ||||||
Dog | DEK proto-oncogene | VGNC:49852 | 610538 | |||||
Horse | DEK proto-oncogene | VGNC:17119 | 100066265 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | DEK proto-oncogene | |||||
Mouse | ||||||
Rat | ||||||
Dog | DEK proto-oncogene | |||||
Horse | DEK proto-oncogene | |||||
Publication Statistics
PubMed Score 308.23
PubMed score by year
PubTator Score 163.60
PubTator score by year
Related Publications
Text Mined References (116)
GeneRif Annotations (84)
Items per page:
0 of 0
PMID | Year | Title |
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