Tbio DEK Protein DEK

Protein Summary

Description

Involved in chromatin organization. This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Uniprot Accession IDs

• P35659
• B2R6K6
• B4DN37
• Q5TGV4
• Q5TGV5

Gene Name

• DEK

Ensembl ID

• ENST00000244776
• ENSP00000244776
• ENSG00000124795
• ENST00000397239
• ENSP00000380414

Symbol

• D6S231E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
kinase perturbation	0.88
transcription factor binding site profile	0.81
microRNA	0.75
disease perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 370.36   (req: < 5)

Gene RIFs: 104   (req: <= 3)

Antibodies: 227   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 370.36   (req: >= 5)

Gene RIFs: 104   (req: > 3)

Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0