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Tbio
DEGS2
Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2

Protein Summary
Description
Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase. This gene encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305631
  • ENSP00000307126
  • ENSG00000168350

Symbol
  • C14orf66
  • DES2
  • FADS8
  • C14orf66
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.71
tissue sample
0.57
tissue
0.49
transcription factor
0.47
cell type or tissue
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.06   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.06   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
ACER3
Tbio
Family:  Enzyme
Novelty:  0.01058501
Score:  0.977
Data Source:  STRINGDB
SGMS1
Tchem
Family:  Enzyme
Novelty:  0.01717229
Score:  0.976
Data Source:  STRINGDB
ACER2
Tchem
Family:  Enzyme
Novelty:  0.040885
Score:  0.964
Data Source:  STRINGDB
SGPP2
Tbio
Family:  Enzyme
Novelty:  0.09408823
Score:  0.964
Data Source:  STRINGDB
SGMS2
Tchem
Family:  Enzyme
Novelty:  0.01360669
Score:  0.963
Data Source:  STRINGDB
KDSR
Tbio
Family:  Enzyme
Novelty:  0.0408411
Score:  0.96
Data Source:  STRINGDB
UGCG
Tclin
Family:  Enzyme
Novelty:  0.00481791
Score:  0.955
Data Source:  STRINGDB
UGT8
Tchem
Family:  Enzyme
Novelty:  0.02518383
Score:  0.951
Data Source:  STRINGDB
ACER1
Tbio
Family:  Enzyme
Novelty:  0.05571844
Score:  0.948
Data Source:  STRINGDB
GALC
Tbio
Family:  Enzyme
Novelty:  0.00203532
Score:  0.946
Data Source:  STRINGDB
Pathways (9)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
4
3
3
6.7
85.5
metastasis measurement
1
2
0
13.4
39.4
disease progression measurement
1
2
0
13.4
39.4
caudate nucleus volume
1
1
0
5.8
8.1
gut microbiome measurement
1
1
1
0.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
3
6.7
85.5
metastasis measurement
0
13.4
39.4
disease progression measurement
0
13.4
39.4
caudate nucleus volume
0
5.8
8.1
gut microbiome measurement
1
0.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
delta 4-desaturase, sphingolipid 2
453157
Mouse
MGI:1917309
70059
Rat
RGD:1305023
314438
Dog
delta 4-desaturase, sphingolipid 2
VGNC:39883
490854
Horse
delta 4-desaturase, sphingolipid 2
VGNC:17118
100049834
Species
Name
OMA
EggNOG
Inparanoid
Chimp
delta 4-desaturase, sphingolipid 2
Mouse
Rat
Dog
delta 4-desaturase, sphingolipid 2
Horse
delta 4-desaturase, sphingolipid 2
Publication Statistics
PubMed Score 64.06
PubMed score by year
PubTator Score 25.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title