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Tbio
DEFB127
Beta-defensin 127

Protein Summary
Description
Has antibacterial activity. Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The antimicrobial protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382388
  • ENSP00000371825
  • ENSG00000088782

Symbol
  • C20orf73
  • DEFB27
  • DEF-27
  • DEFB27
  • hBD-27
  • DEFB-27
  • C20orf73
  • bA530N10.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.45
cell line
0.44
cell type or tissue
0.41
virus perturbation
0.41
protein complex
0.4


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.92   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 6   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.92   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 6   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
HTRA1
Tchem
Family:  Enzyme
Novelty:  0.0016879
p_int:  0.999498869
p_ni:  0.000501109
p_wrong:  2.2e-8
Score:  0.157
Data Source:  BioPlex,STRINGDB
ACTR10
Tbio
Novelty:  0.11388846
p_int:  0.999326072
p_ni:  0.000673928
Score:  0.691
Data Source:  BioPlex,STRINGDB
DCTN6
Tdark
Novelty:  0.30624393
p_int:  0.999202096
p_ni:  0.000797904
Score:  0.811
Data Source:  BioPlex,STRINGDB
DCTN5
Tbio
Novelty:  0.19530162
p_int:  0.997551362
p_ni:  0.002448637
Score:  0.819
Data Source:  BioPlex,STRINGDB
SH3BGR
Tbio
Novelty:  0.19912265
p_int:  0.995441226
p_ni:  0.004558766
p_wrong:  8e-9
Score:  0.193
Data Source:  BioPlex,STRINGDB
DCTN3
Tbio
Novelty:  0.14551388
p_int:  0.994601085
p_ni:  0.005398915
Score:  0.817
Data Source:  BioPlex,STRINGDB
DCTN4
Tbio
Novelty:  0.10319227
p_int:  0.991836052
p_ni:  0.008163948
Score:  0.69
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.969562561
p_ni:  0.030437439
Data Source:  BioPlex
ACTR1B
Tbio
Novelty:  0.10014723
p_int:  0.967584036
p_ni:  0.032415964
Score:  0.812
Data Source:  BioPlex,STRINGDB
ACTR1A
Tbio
Novelty:  0.06306209
p_int:  0.939015081
p_ni:  0.060984919
Score:  0.811
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
defensin beta 127
VGNC:13844
745453
Dog
defensin beta 127
VGNC:39880
100135060
Species
Name
OMA
EggNOG
Inparanoid
Chimp
defensin beta 127
Dog
defensin beta 127
Publication Statistics
PubMed Score 6.92
PubMed score by year
PubTator Score 2.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title