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Tdark
DEFB121
Beta-defensin 121

Protein Summary
Description
Has antibacterial activity. This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376314
  • ENSP00000417128
  • ENSG00000204548

Symbol
  • DEFB21
  • DEFB21
  • ESC42RELC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.36
biological term
0.33
cell line
0.33
tissue
0.33
pathway
0.32


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.27   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.27   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
TCTEX1D2
Tbio
Novelty:  0.15075459
p_int:  0.999152242
p_ni:  0.000834781
p_wrong:  0.000012977
Score:  0.189
Data Source:  BioPlex,STRINGDB
VWDE
Tdark
Novelty:  0.37298162
p_int:  0.991131441
p_ni:  0.008858829
p_wrong:  0.00000973
Score:  0.243
Data Source:  BioPlex,STRINGDB
CPS1
Tclin
Family:  Enzyme
Novelty:  0.00917469
p_int:  0.989052929
p_ni:  0.010947071
Data Source:  BioPlex
COL6A2
Tbio
Novelty:  0.01275082
p_int:  0.986183443
p_ni:  0.013816555
p_wrong:  2e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
TMEM67
Tbio
Novelty:  0.02573267
p_int:  0.96363693
p_ni:  0.036353814
p_wrong:  0.000009257
Score:  0.185
Data Source:  BioPlex,STRINGDB
OS9
Tbio
Novelty:  0.01490339
p_int:  0.923125973
p_ni:  0.076874027
Data Source:  BioPlex
NHLRC3
Tdark
Novelty:  1.23813202
p_int:  0.807390897
p_ni:  0.191487706
p_wrong:  0.001121397
Score:  0.309
Data Source:  BioPlex,STRINGDB
FSTL1
Tbio
Novelty:  0.00557848
p_int:  0.768138093
p_ni:  0.21864963
p_wrong:  0.013212277
Score:  0.185
Data Source:  BioPlex,STRINGDB
DEFB110
Tdark
Novelty:  0.49548192
Score:  0.98
Data Source:  STRINGDB
DEFB119
Tbio
Novelty:  0.36154966
Score:  0.977
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
36.9
alkaline phosphatase measurement
1
1
1
32.6
smoking behavior
1
1
1
24.5
smoking initiation
1
1
1
14.2
smoking status measurement
1
1
1
12.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
36.9
alkaline phosphatase measurement
1
32.6
smoking behavior
1
24.5
smoking initiation
1
14.2
smoking status measurement
1
12.2
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
defensin beta 121
VGNC:6090
746082
Macaque
defensin beta 121 [Source:HGNC Symbol;Acc:HGNC:18101]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
defensin beta 121
Macaque
defensin beta 121 [Source:HGNC Symbol;Acc:HGNC:18101]
Publication Statistics
PubMed Score 0.27
PubMed score by year
PubTator Score 0.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title