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Tbio
DEFB118
Beta-defensin 118

Protein Summary
Description
Has antibacterial activity. This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. Expression of this gene is regulated by androgen, and the encoded protein binds to sperm and exhibits antibacterial activity against E. coli. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253381
  • ENSP00000253381
  • ENSG00000131068

Symbol
  • C20orf63
  • DEFB18
  • ESC42
  • ESC42
  • DEFB-18
  • ESP13.6
  • C20orf63
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.48
phenotype
0.46
cell line
0.4
biological term
0.33
microRNA
0.33


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 12   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 12   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
DEFB132
Tdark
Novelty:  0.43147041
Score:  0.979
Data Source:  STRINGDB
DEFB126
Tbio
Novelty:  0.05538355
Score:  0.973
Data Source:  STRINGDB
DEFB114
Tbio
Novelty:  0.22206668
Score:  0.968
Data Source:  STRINGDB
DEFB127
Tbio
Novelty:  0.18126756
Score:  0.968
Data Source:  STRINGDB
DEFB116
Tdark
Novelty:  2.72622256
Score:  0.962
Data Source:  STRINGDB
DEFB135
Tdark
Novelty:  2.04107063
Score:  0.956
Data Source:  STRINGDB
DEFB124
Tbio
Novelty:  1.65330827
Score:  0.946
Data Source:  STRINGDB
DEFB119
Tbio
Novelty:  0.36154966
Score:  0.945
Data Source:  STRINGDB
DEFB129
Tdark
Novelty:  0.26809608
Score:  0.943
Data Source:  STRINGDB
DEFB1
Tbio
Novelty:  0.00144458
Score:  0.934
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
56.8
smoking behavior
1
1
1
30.2
alkaline phosphatase measurement
1
1
1
21.6
smoking initiation
1
1
1
11.4
smoking status measurement
1
1
1
9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
56.8
smoking behavior
1
30.2
alkaline phosphatase measurement
1
21.6
smoking initiation
1
11.4
smoking status measurement
1
9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Rat
RGD:1562393
641636
Dog
defensin beta 118
100683741
Species
Name
OMA
EggNOG
Inparanoid
Rat
Dog
defensin beta 118
Publication Statistics
PubMed Score 9.39
PubMed score by year
PubTator Score 3.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title