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Tdark
DEFB107A
Beta-defensin 107

Protein Summary
Description
Has antibacterial activity. Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 107, DEFB107A and DEFB107B, in tail-to-tail orientation. This gene, DEFB107A, represents the more centromeric copy. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335021
  • ENSP00000334681
  • ENSG00000186572
  • ENST00000355602
  • ENSP00000347810
  • ENSG00000198129
  • ENST00000615431
  • ENSP00000478422
  • ENSG00000277530
  • ENST00000642785
  • ENSP00000495534
  • ENSG00000285432
  • ENST00000646983
  • ENSP00000493774
  • ENSG00000284979

Symbol
  • DEFB107
  • DEFB7
  • BD-7
  • DEFB-7
  • DEFB107
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.77
phenotype
0.36
disease
0.34
tissue
0.34
biological term
0.32


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.29   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.29   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
DEFB106A
Tbio
Novelty:  0.0474196
Score:  0.862
Data Source:  STRINGDB
DEFB105A
Tbio
Novelty:  0.03235589
Score:  0.832
Data Source:  STRINGDB
DEFB104A
Tbio
Novelty:  0.0468791
Score:  0.799
Data Source:  STRINGDB
DEFB108B
Tdark
Novelty:  0.4704814
Score:  0.768
Data Source:  STRINGDB
PRR23C
Tdark
Novelty:  12.37276933
Score:  0.739
Data Source:  STRINGDB
DEFB1
Tbio
Novelty:  0.00144458
Score:  0.731
Data Source:  STRINGDB
DEFB103A
Tbio
Novelty:  0.00328986
Score:  0.731
Data Source:  STRINGDB
USP17L8
Tdark
Family:  Enzyme
Novelty:  9.5249549
Score:  0.676
Data Source:  STRINGDB
PRR23A
Tdark
Novelty:  15.74603175
Score:  0.675
Data Source:  STRINGDB
USP17L4
Tdark
Family:  Enzyme
Novelty:  11.52
Score:  0.669
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 4.29
PubMed score by year
PubTator Score 0.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title