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Tbio
DEFB104A
Beta-defensin 104

Protein Summary
Description
Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103. Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation. This gene, DEFB104A, represents the more centromeric copy. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314265
  • ENSP00000320813
  • ENSG00000176782
  • ENST00000316169
  • ENSP00000322191
  • ENSG00000177023
  • ENST00000616398
  • ENSP00000481976
  • ENSG00000277006
  • ENST00000644603
  • ENSP00000494390
  • ENSG00000285034
  • ENST00000646913
  • ENSP00000494886

Symbol
  • DEFB104
  • DEFB4
  • BD-4
  • DEFB4
  • hBD-4
  • DEFB-4
  • DEFB104
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.77
disease
0.58
phenotype
0.38
biological term
0.35
tissue
0.31


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.63   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.63   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
RMND1
Tbio
Novelty:  0.06181833
p_int:  0.999343455
p_ni:  0.000656545
Data Source:  BioPlex
GNB2
Tbio
Novelty:  0.08682553
p_int:  0.991422693
p_ni:  0.008577307
Data Source:  BioPlex
IFI30
Tbio
Family:  Enzyme
Novelty:  0.00939681
p_int:  0.960192637
p_ni:  0.000180348
p_wrong:  0.039627015
Data Source:  BioPlex
PITRM1
Tchem
Family:  Enzyme
Novelty:  0.08067518
p_int:  0.945686757
p_ni:  0.054313243
Data Source:  BioPlex
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
p_int:  0.87613217
p_ni:  0.123850369
p_wrong:  0.000017461
Data Source:  BioPlex
PTPRG
Tchem
Family:  Enzyme
Novelty:  0.01920574
p_int:  0.75079105
p_ni:  0.249208948
p_wrong:  1e-9
Data Source:  BioPlex
DEFB107A
Tdark
Novelty:  0.20848172
Score:  0.799
Data Source:  STRINGDB
DEFB103A
Tbio
Novelty:  0.00328986
Score:  0.772
Data Source:  STRINGDB
DEFB106A
Tbio
Novelty:  0.0474196
Score:  0.77
Data Source:  STRINGDB
DEFB105A
Tbio
Novelty:  0.03235589
Score:  0.768
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
defensin, beta 104
735929
Species
Name
OMA
EggNOG
Inparanoid
Chimp
defensin, beta 104
Publication Statistics
PubMed Score 19.63
PubMed score by year
PubTator Score 33.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title