Tbio DEFB103A Beta-defensin 103

Protein Summary

Description

Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 103, an antibiotic peptide which is induced by bacteria and interferon gamma, and which displays antimicrobial activity against S. aureus, S. pyogenes, P. aeruginosa, E. coli, and C. albicans. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• P81534
• Q8NFG6
• Q9NPF6

Gene Name

• DEFB103A

Ensembl ID

• ENST00000314357
• ENSP00000320951
• ENSG00000176797
• ENST00000318124
• ENSP00000324633
• ENSG00000177243
• ENST00000613448
• ENSP00000480773
• ENSG00000273641
• ENST00000642635
• ENSP00000495040
• ENSG00000285376
• ENST00000646258
• ENSP00000493640
• ENST00000646344
• ENSP00000493616
• ENSG00000284978

Symbol

• BD3
• DEFB103
• DEFB3
• BD-3
• HBD3
• HBP3
• DEFB3
• HBP-3
• DEFB-3
• DEFB103

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.85
disease	0.57
cell line	0.54
tissue	0.47
phenotype	0.41

Protein Classes

PANTHER Classes

Protein / Defense/immunity Protein / Antibacterial Response Protein / Beta-defensin 103

DTO Classes

Protein / Immune Response / Antibacterial Response Protein / Beta-defensin 103

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 386.51   (req: < 5)

Gene RIFs: 149   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 386.51   (req: >= 5)

Gene RIFs: 149   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0