You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DEFB1
Beta-defensin 1

Protein Summary
Description
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636). Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297439
  • ENSP00000297439
  • ENSG00000164825
  • ENST00000642865
  • ENSP00000494448
  • ENSG00000284881

Symbol
  • BD1
  • HBD1
  • BD1
  • HBD1
  • DEFB-1
  • DEFB101
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.89
cell type or tissue
0.73
disease
0.72
gene perturbation
0.7
tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 736.89   (req: < 5)
Gene RIFs: 150   (req: <= 3)
Antibodies: 431   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 736.89   (req: >= 5)
Gene RIFs: 150   (req: > 3)
Antibodies: 431   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
FBXW5
Tbio
Novelty:  0.13100873
p_int:  0.999993122
p_ni:  0.000006841
p_wrong:  3.8e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
FAM172A
Tbio
Novelty:  0.1200899
p_int:  0.998340371
p_ni:  0.001627757
p_wrong:  0.000031872
Score:  0.209
Data Source:  BioPlex,STRINGDB
PM20D2
Tdark
Family:  Enzyme
Novelty:  0.63491472
p_int:  0.995213617
p_ni:  0.004786383
Score:  0.228
Data Source:  BioPlex,STRINGDB
NMT2
Tchem
Family:  Enzyme
Novelty:  0.04826835
p_int:  0.914874129
p_ni:  0.085116335
p_wrong:  0.000009536
Score:  0.173
Data Source:  BioPlex,STRINGDB
NMT1
Tchem
Family:  Enzyme
Novelty:  0.00343834
p_int:  0.893386445
p_ni:  0.106613555
Score:  0.163
Data Source:  BioPlex,STRINGDB
PMPCA
Tbio
Family:  Enzyme
Novelty:  0.01842996
p_int:  0.76058393
p_ni:  0.23941607
Score:  0.67
Data Source:  BioPlex,STRINGDB
PMPCB
Tbio
Family:  Enzyme
Novelty:  0.0244013
p_int:  0.759220858
p_ni:  0.240779142
Score:  0.549
Data Source:  BioPlex,STRINGDB
IDE
Tchem
Family:  Enzyme
Novelty:  0.00207793
p_int:  0.7558736
p_ni:  0.2441264
Score:  0.195
Data Source:  BioPlex,STRINGDB
DEFB127
Tbio
Novelty:  0.18126756
Score:  0.973
Data Source:  STRINGDB
DEFA3
Tbio
Novelty:  0.04840173
Score:  0.966
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Defensins
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Defensins
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil percentage of leukocytes
2
5
5
96.9
basophil percentage of leukocytes
2
5
5
96.9
basophil count
2
4
4
96.8
basophil count
2
4
4
96.8
monocyte percentage of leukocytes
2
3
3
96.1
Items per page:
1 – 5 of 24
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil percentage of leukocytes
5
96.9
basophil percentage of leukocytes
5
96.9
basophil count
4
96.8
basophil count
4
96.8
monocyte percentage of leukocytes
3
96.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
defensin beta 1
VGNC:11964
450100
Mouse
MGI:1096878
13214
Rat
RGD:619943
83687
Dog
defensin beta 1
VGNC:39876
611241
Pig
defensin beta 1
404699
Species
Name
OMA
EggNOG
Inparanoid
Chimp
defensin beta 1
Mouse
Rat
Dog
defensin beta 1
Pig
defensin beta 1
Publication Statistics
PubMed Score 736.89
PubMed score by year
PubTator Score 376.77
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title