Protein Summary
Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing. Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq, Oct 2014]
- ENST00000330590
- ENSP00000329890
- ENSG00000164816
- ENST00000647159
- ENSP00000494799
- ENSG00000285251
- DEF5
- DEF5
- HD-5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.93 | ||
biological term | 0.63 | ||
cellular component | 0.59 | ||
protein domain | 0.58 | ||
phenotype | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 127.84 (req: < 5)
Gene RIFs: 54 (req: <= 3)
Antibodies: 232 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 127.84 (req: >= 5)
Gene RIFs: 54 (req: > 3)
Antibodies: 232 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (121)
SHLD2
Novelty: 0.55336226
p_int: 0.99999881
p_ni: 9.3e-8
p_wrong: 0.000001097
Score: 0.187
Data Source: BioPlex,STRINGDB
CILP2
Novelty: 0.07992715
p_int: 0.999988924
p_ni: 3.53e-7
p_wrong: 0.000010723
Data Source: BioPlex
GLCE
Family: Enzyme
Novelty: 0.0497423
p_int: 0.999984485
p_ni: 0.000015514
p_wrong: 1e-9
Data Source: BioPlex
IP6K1
Family: Kinase
Novelty: 0.03418032
p_int: 0.999974782
p_ni: 0.000025218
Data Source: BioPlex
CEP170B
Novelty: 0.30498676
p_int: 0.999928311
p_ni: 0.000066615
p_wrong: 0.000005074
Data Source: BioPlex
Nearest Tclin Targets
Pathways (7)
Reactome (5)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Alpha-defensins | ||||
Reactome | Antimicrobial peptides | ||||
Reactome | Defensins | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Alpha-defensins | ||||
Antimicrobial peptides | ||||
Defensins | ||||
Immune System | ||||
Innate Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (1)
Components (5)
Processes (12)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 2 | 6 | 7 | 98.4 | ||||||
monocyte percentage of leukocytes | 2 | 6 | 7 | 98.4 | ||||||
basophil count | 3 | 8 | 10 | 98.3 | ||||||
basophil count | 3 | 8 | 10 | 98.3 | ||||||
basophil percentage of leukocytes | 2 | 7 | 7 | 97.8 | ||||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 7 | 98.4 | |||||
monocyte percentage of leukocytes | 7 | 98.4 | |||||
basophil count | 10 | 98.3 | |||||
basophil count | 10 | 98.3 | |||||
basophil percentage of leukocytes | 7 | 97.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (2)
1 – 2 of 2
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Rat | RGD:727951 | 286995 | ||||||
Rat | RGD:727857 | 286958 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Rat | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 127.84
PubMed score by year
PubTator Score 116.67
PubTator score by year
Related Publications
Text Mined References (70)
GeneRif Annotations (54)
Items per page:
0 of 0
PMID | Year | Title |
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