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Tbio
DEF8
Differentially expressed in FDCP 8 homolog

Protein Summary
Description
Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268676
  • ENSP00000268676
  • ENSG00000140995
  • ENST00000418391
  • ENSP00000412784
  • ENST00000563594
  • ENSP00000458019
  • ENST00000563795
  • ENSP00000457627
  • ENST00000567874
  • ENSP00000456095
  • ENST00000569453
  • ENSP00000456501
  • ENST00000570182
  • ENSP00000456799
  • ENST00000610455
  • ENSP00000480073
  • ENST00000617948
  • ENSP00000482524
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
metabolite
0.82
histone modification site profile
0.81
tissue sample
0.72
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.87   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.87   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (74)
WDFY3
Tbio
Novelty:  0.01670166
p_int:  0.999987246
p_ni:  0.000012754
p_wrong:  1e-9
Score:  0.29
Data Source:  BioPlex,STRINGDB
PKN3
Tchem
Family:  Kinase
Novelty:  0.0516816
p_int:  0.99994811
p_ni:  0.00005189
Data Source:  BioPlex
APAF1
Tchem
Family:  Enzyme
Novelty:  0.00107622
p_int:  0.999928773
p_ni:  0.00007122
p_wrong:  7e-9
Score:  0.18
Data Source:  BioPlex,STRINGDB
PLCB1
Tbio
Family:  Enzyme
Novelty:  0.00269771
p_int:  0.999864744
p_ni:  0.000034933
p_wrong:  0.000100323
Score:  0.189
Data Source:  BioPlex,STRINGDB
RADIL
Tbio
Novelty:  0.08747353
p_int:  0.99966657
p_ni:  0.000333428
p_wrong:  2e-9
Score:  0.2
Data Source:  BioPlex,STRINGDB
HPS5
Tbio
Novelty:  0.05155851
p_int:  0.999576535
p_ni:  0.000423465
Score:  0.179
Data Source:  BioPlex,STRINGDB
KDM5C
Tchem
Family:  TF; Epigenetic
Novelty:  0.00701855
p_int:  0.997922044
p_ni:  0.002077929
p_wrong:  2.7e-8
Score:  0.156
Data Source:  BioPlex,STRINGDB
MSTO1
Tbio
Novelty:  0.05914188
p_int:  0.993208951
p_ni:  0.006791048
p_wrong:  1e-9
Data Source:  BioPlex
ZMYM6
Tbio
Novelty:  0.4933879
p_int:  0.976033373
p_ni:  0.023966627
Score:  0.55
Data Source:  BioPlex,STRINGDB
STIL
Tbio
Novelty:  0.01053211
p_int:  0.974115554
p_ni:  0.025884441
p_wrong:  6e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
10
30
1
2.4
99.9
suntan
3
8
8
99.7
hair colour measurement
2
7
7
99.2
4
3
2
1.4
99.2
3
3
0
1.3
98.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
2.4
99.9
suntan
8
99.7
hair colour measurement
7
99.2
2
1.4
99.2
0
1.3
98.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
differentially expressed in FDCP 8 homolog
699856
Mouse
MGI:1346331
23854
Rat
RGD:1309008
307973
Dog
differentially expressed in FDCP 8 homolog
VGNC:39875
489651
Horse
differentially expressed in FDCP 8 homolog
VGNC:51173
100052770
Species
Name
OMA
EggNOG
Inparanoid
Macaque
differentially expressed in FDCP 8 homolog
Mouse
Rat
Dog
differentially expressed in FDCP 8 homolog
Horse
differentially expressed in FDCP 8 homolog
Publication Statistics
PubMed Score 6.87
PubMed score by year
PubTator Score 0.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title