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Tbio
DEDD
Death effector domain-containing protein

Protein Summary
Description
A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity). This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 20 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368006
  • ENSP00000356985
  • ENSG00000158796
  • ENST00000458050
  • ENSP00000414821
  • ENST00000490843
  • ENSP00000476946
  • ENST00000545495
  • ENSP00000445835

Symbol
  • DEDPRO1
  • DEFT
  • DEFT
  • KE05
  • DEDD1
  • FLDED1
  • CASP8IP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
histone modification site profile
0.85
disease perturbation
0.74
transcription factor perturbation
0.74
microRNA
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999886627
p_ni:  0.000113241
p_wrong:  1.31e-7
Data Source:  BioPlex
DNAJC3
Tbio
Novelty:  0.02129782
p_int:  0.998993534
p_ni:  0.000926596
p_wrong:  0.00007987
Data Source:  BioPlex
ERI1
Tbio
Family:  Enzyme
Novelty:  0.00959105
Score:  0.805
Data Source:  STRINGDB
RNF34
Tbio
Family:  Enzyme
Novelty:  0.04365307
Score:  0.8
Data Source:  STRINGDB
PARN
Tbio
Family:  Enzyme
Novelty:  0.00738516
Score:  0.755
Data Source:  STRINGDB
SLBP
Tbio
Novelty:  0.00685735
Score:  0.744
Data Source:  STRINGDB
CASP8
Tchem
Family:  Enzyme
Novelty:  0.00024321
Score:  0.739
Data Source:  STRINGDB
CNOT8
Tbio
Novelty:  0.01700084
Score:  0.739
Data Source:  STRINGDB
KRT18
Tbio
Novelty:  0.00069055
Score:  0.727
Data Source:  STRINGDB
CNOT7
Tchem
Novelty:  0.04551853
Score:  0.726
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (39)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
2
2
92.2
high density lipoprotein cholesterol measurement
32
3
32
92
4
2
0
1.1
90
asthma
6
2
1
1
84.5
mean platelet volume
3
2
4
84.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
92.2
high density lipoprotein cholesterol measurement
32
92
0
1.1
90
asthma
1
1
84.5
mean platelet volume
4
84.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
death effector domain containing
VGNC:6743
457448
Macaque
death effector domain containing
719875
Mouse
MGI:1333874
21945
Rat
RGD:620050
83631
Dog
death effector domain containing
VGNC:39872
488649
Species
Name
OMA
EggNOG
Inparanoid
Chimp
death effector domain containing
Macaque
death effector domain containing
Mouse
Rat
Dog
death effector domain containing
Publication Statistics
PubMed Score 76.00
PubMed score by year
PubTator Score 10.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title