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Tbio
DECR2
Peroxisomal 2,4-dienoyl-CoA reductase

Protein Summary
Description
Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219481
  • ENSP00000219481
  • ENSG00000242612
  • ENST00000439661
  • ENSP00000399697
  • ENST00000613476
  • ENSP00000481547
  • ENSG00000274296
  • ENST00000631856
  • ENSP00000488824

Symbol
  • PDCR
  • SDR17C1
  • PDCR
  • SDR17C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
cell type or tissue
0.69
gene perturbation
0.63
histone modification site profile
0.63
cell line
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.5   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.5   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
PDZK1P1
Tdark
p_int:  0.967475651
p_ni:  0.032524349
Data Source:  BioPlex
SESTD1
Tbio
Novelty:  0.2052002
p_int:  0.935719941
p_ni:  0.000785682
p_wrong:  0.063494376
Score:  0.537
Data Source:  BioPlex,STRINGDB
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.79985313
p_ni:  0.20014687
Score:  0.186
Data Source:  BioPlex,STRINGDB
HSD17B4
Tbio
Novelty:  0.00547499
Score:  0.974
Data Source:  STRINGDB
ACOX2
Tbio
Family:  Enzyme
Novelty:  0.02942359
Score:  0.955
Data Source:  STRINGDB
ECH1
Tbio
Family:  Enzyme
Novelty:  0.02471875
Score:  0.955
Data Source:  STRINGDB
EHHADH
Tbio
Novelty:  0.00878193
Score:  0.954
Data Source:  STRINGDB
CRAT
Tbio
Family:  Enzyme
Novelty:  0.01242609
Score:  0.953
Data Source:  STRINGDB
ACOX1
Tchem
Family:  Enzyme
Novelty:  0.00473427
Score:  0.951
Data Source:  STRINGDB
ACOT8
Tbio
Family:  Enzyme
Novelty:  0.02218214
Score:  0.95
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Beta-oxidation of very long chain fatty acids (R-HSA-390247)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-oxidation of very long chain fatty acids
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Peroxisomal lipid metabolism
Name
Explore in Pharos
Explore in Source
Beta-oxidation of very long chain fatty acids
Fatty acid metabolism
Metabolism
Metabolism of lipids
Peroxisomal lipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (42)
Items per page:
1 – 5 of 42
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
5
11
98.2
heel bone mineral density
3
5
11
98.2
mean corpuscular hemoglobin concentration
3
4
5
96
mean corpuscular hemoglobin concentration
3
4
5
96
platelet count
2
2
2
90.6
Items per page:
1 – 5 of 42
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
11
98.2
heel bone mineral density
11
98.2
mean corpuscular hemoglobin concentration
5
96
mean corpuscular hemoglobin concentration
5
96
platelet count
2
90.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
2,4-dienoyl-CoA reductase 2
100608945
Macaque
2,4-dienoyl-CoA reductase 2
695540
Mouse
MGI:1347059
26378
Rat
Dog
2,4-dienoyl-CoA reductase 2
VGNC:54016
100688128
Species
Name
OMA
EggNOG
Inparanoid
Chimp
2,4-dienoyl-CoA reductase 2
Macaque
2,4-dienoyl-CoA reductase 2
Mouse
Rat
Dog
2,4-dienoyl-CoA reductase 2
Publication Statistics
PubMed Score 23.50
PubMed score by year
PubTator Score 4.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title