You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DEAF1
Deformed epidermal autoregulatory factor 1 homolog

Protein Summary
Description
Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase. Required for neural tube closure and skeletal patterning. Regulates epithelial cell proliferation and side-branching in the mammary gland. Controls the expression of peripheral tissue antigens in pancreatic lymph nodes. Isoform 1 displays greater transcriptional activity than isoform 4. Isoform 4 may inhibit transcriptional activity of isoform 1 by interacting with isoform 1 and retaining it in the cytoplasm. Transcriptional activator of EIF4G3. This gene encodes a zinc finger domain-containing protein that func ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.85
virus perturbation
0.79
gene perturbation
0.71
transcription factor binding site profile
0.71
cell type or tissue
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.42   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 303   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.42   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 303   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
BSPRY
Tdark
Novelty:  0.38200913
p_int:  0.999997368
p_wrong:  0.000002632
Score:  0.282
Data Source:  BioPlex,STRINGDB
ZMYND19
Tdark
Novelty:  0.3590069
Score:  0.819
Data Source:  STRINGDB
ZMYND11
Tbio
Family:  Epigenetic
Novelty:  0.02485283
Score:  0.8
Data Source:  STRINGDB
HTR1A
Tclin
Family:  GPCR
Novelty:  0.00015658
Score:  0.778
Data Source:  STRINGDB
GATD1
Tdark
Family:  Enzyme
Novelty:  0.40291197
Score:  0.741
Data Source:  STRINGDB
RAN
Tchem
Family:  Enzyme
Novelty:  0.00160888
Score:  0.74
Data Source:  STRINGDB
EIF4G3
Tbio
Novelty:  0.03002723
Score:  0.715
Data Source:  STRINGDB
AIRE
Tbio
Family:  TF; Epigenetic
Novelty:  0.00158659
Score:  0.682
Data Source:  STRINGDB
AGBL5
Tbio
Family:  Enzyme
Novelty:  0.05735805
Score:  0.682
Data Source:  STRINGDB
CC2D1A
Tbio
Novelty:  0.01970021
Score:  0.674
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
7
0
1.2
91.3
intraocular pressure measurement
1
2
2
80.2
1
1
1
77.9
2
2
0
1.2
46.9
waist-hip ratio
2
3
3
38.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
91.3
intraocular pressure measurement
2
80.2
1
77.9
0
1.2
46.9
waist-hip ratio
3
38.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAF1, transcription factor
VGNC:3135
373853
Macaque
DEAF1, transcription factor
720821
Mouse
MGI:1858496
54006
Rat
RGD:620671
83632
Dog
DEAF1, transcription factor
VGNC:39870
483409
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAF1, transcription factor
Macaque
DEAF1, transcription factor
Mouse
Rat
Dog
DEAF1, transcription factor
Publication Statistics
PubMed Score 92.42
PubMed score by year
PubTator Score 278.30
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title