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Tdark
DDX55
ATP-dependent RNA helicase DDX55

Protein Summary
Description
Probable ATP-binding RNA helicase. This gene encodes a member of protein family containing a characteristic Asp-Glu-Ala-Asp (DEAD) motif. These proteins are putative RNA helicases, and may be involved in a range of nuclear processes including translational initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Multiple alternatively spliced transcript variants have been found for this gene. Pseudogenes have been identified on chromosomes 1 and 12. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238146
  • ENSP00000238146
  • ENSG00000111364
  • ENST00000421670
  • ENSP00000442332

Symbol
  • KIAA1595
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
drug perturbation
0.96
molecular function
0.95
protein domain
0.92
histone modification site profile
0.89


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.26   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.26   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (402)
MRPS34
Tbio
Novelty:  0.29355603
p_int:  0.999908151
p_ni:  0.000091849
Score:  0.261
Data Source:  BioPlex,STRINGDB
MRPS17
Tdark
Novelty:  0.46103276
p_int:  0.998664501
p_ni:  0.001335286
p_wrong:  2.13e-7
Data Source:  BioPlex
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.99865793
p_ni:  0.001341625
p_wrong:  4.44e-7
Score:  0.502
Data Source:  BioPlex,STRINGDB
MRPS18B
Tbio
Novelty:  0.14519418
p_int:  0.997529248
p_ni:  0.002364716
p_wrong:  0.000106035
Data Source:  BioPlex
NOL12
Tbio
Novelty:  0.15925205
p_int:  0.993900913
p_ni:  0.006099062
p_wrong:  2.6e-8
Score:  0.555
Data Source:  BioPlex,STRINGDB
FGF8
Tbio
Novelty:  0.00155113
p_int:  0.991171477
p_ni:  0.003844031
p_wrong:  0.004984491
Data Source:  BioPlex
MRPS25
Tdark
Novelty:  0.59354314
p_int:  0.988665331
p_ni:  0.011326824
p_wrong:  0.000007845
Score:  0.377
Data Source:  BioPlex,STRINGDB
HIST1H1E
Tbio
Novelty:  0.01125284
p_int:  0.975646079
p_ni:  0.024353921
Score:  0.245
Data Source:  BioPlex,STRINGDB
MRPS11
Tdark
Novelty:  0.29449255
p_int:  0.898551676
p_ni:  0.081523564
p_wrong:  0.01992476
Score:  0.255
Data Source:  BioPlex,STRINGDB
DDX56
Tbio
Family:  Enzyme
Novelty:  0.03330582
Score:  0.985
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
12
12
94.1
BMI-adjusted waist-hip ratio
1
12
12
93.5
waist circumference
1
7
7
89.8
BMI-adjusted waist circumference
1
9
9
89.3
alkaline phosphatase measurement
1
1
1
67.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
12
94.1
BMI-adjusted waist-hip ratio
12
93.5
waist circumference
7
89.8
BMI-adjusted waist circumference
9
89.3
alkaline phosphatase measurement
1
67.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 55
VGNC:12930
745267
Macaque
DEAD-box helicase 55
709884
Mouse
MGI:1915098
67848
Rat
RGD:2324094
100362764
Dog
DEAD-box helicase 55
VGNC:39865
486246
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 55
Macaque
DEAD-box helicase 55
Mouse
Rat
Dog
DEAD-box helicase 55
Publication Statistics
PubMed Score 3.26
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title