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Tbio
DDX53
Probable ATP-dependent RNA helicase DDX53

Protein Summary
Description
This intronless gene encodes a protein which contains several domains found in members of the DEAD-box helicase protein family. Other members of this protein family participate in ATP-dependent RNA unwinding. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327968
  • ENSP00000368667
  • ENSG00000184735

Symbol
  • CAGE
  • CAGE
  • CT26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.93
tissue
0.63
cell type or tissue
0.51
cell line
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1320.65   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1320.65   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
DDX43
Tbio
Family:  Enzyme
Novelty:  0.0234885
p_int:  0.998681574
p_wrong:  0.001318426
Score:  0.701
Data Source:  BioPlex,STRINGDB
VEGFA
Tclin
Novelty:  0.0000378
Score:  0.724
Data Source:  STRINGDB
SLC43A1
Tbio
Family:  Transporter
Novelty:  0.06939259
Score:  0.71
Data Source:  STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
Score:  0.676
Data Source:  STRINGDB
EMB
Tbio
Novelty:  0.00135577
Score:  0.669
Data Source:  STRINGDB
PPP1R15A
Tchem
Family:  Enzyme
Novelty:  0.00529607
Score:  0.644
Data Source:  STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.643
Data Source:  STRINGDB
S100A8
Tbio
Novelty:  0.00107914
Score:  0.635
Data Source:  STRINGDB
CALR
Tbio
Novelty:  0.0004479
Score:  0.628
Data Source:  STRINGDB
CTLA4
Tclin
Novelty:  0.00012781
Score:  0.578
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
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1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 53
VGNC:12289
473531
Horse
DEAD-box helicase 53
VGNC:17102
100059799
Cow
DEAD-box helicase 53 [Source:HGNC Symbol;Acc:HGNC:20083]
Pig
DEAD-box helicase 53
100524536
Xenopus
DEAD-box helicase 43
XB-GENE-988016
779928
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 53
Horse
DEAD-box helicase 53
Cow
DEAD-box helicase 53 [Source:HGNC Symbol;Acc:HGNC:20083]
Pig
DEAD-box helicase 53
Xenopus
DEAD-box helicase 43
Publication Statistics
PubMed Score 1320.65
PubMed score by year
PubTator Score 712.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title