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Tbio
DDX52
Probable ATP-dependent RNA helicase DDX52

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000615769
  • ENSP00000480030
  • ENSG00000277594
  • ENST00000617633
  • ENSP00000479504
  • ENSG00000278053

Symbol
  • ROK1
  • ROK1
  • HUSSY19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
virus perturbation
0.99
molecular function
0.94
histone modification site profile
0.85
hub protein
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.93   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.93   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (342)
CHCHD4
Tbio
Novelty:  0.01204944
p_int:  0.999450747
p_ni:  0.00054925
p_wrong:  4e-9
Data Source:  BioPlex
DCAF8L2
Tdark
Novelty:  6.73057868
p_int:  0.986956665
p_ni:  0.012592889
p_wrong:  0.000450447
Data Source:  BioPlex
ZNF22
Tbio
Family:  TF
Novelty:  0.12323788
p_int:  0.969988177
p_ni:  0.030011808
p_wrong:  1.5e-8
Score:  0.827
Data Source:  BioPlex,STRINGDB
RPL14
Tbio
Novelty:  0.01600377
p_int:  0.969988177
p_ni:  0.030011808
p_wrong:  1.5e-8
Score:  0.526
Data Source:  BioPlex,STRINGDB
HIST1H1T
Tdark
Novelty:  0.01039464
p_int:  0.969988177
p_ni:  0.030011808
p_wrong:  1.5e-8
Data Source:  BioPlex
CCDC59
Tbio
Novelty:  0.05894885
p_int:  0.955363446
p_ni:  0.044598253
p_wrong:  0.000038301
Score:  0.228
Data Source:  BioPlex,STRINGDB
RPL18
Tbio
Novelty:  0.01765545
p_int:  0.897838408
p_ni:  0.10216159
p_wrong:  2e-9
Data Source:  BioPlex
ZNF324B
Tdark
Family:  TF
Novelty:  1.89922228
p_int:  0.89123879
p_ni:  0.108706729
p_wrong:  0.000054482
Data Source:  BioPlex
GPATCH4
Tdark
Novelty:  1.13040547
p_int:  0.870116783
p_ni:  0.12988267
p_wrong:  5.47e-7
Score:  0.697
Data Source:  BioPlex,STRINGDB
TIMM8A
Tbio
Family:  Enzyme
Novelty:  0.00954602
p_int:  0.84594206
p_ni:  0.154057602
p_wrong:  3.38e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (72)
Items per page:
1 – 5 of 72
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
11
5
0
1.2
98.9
11
5
0
1.2
98.9
11
7
4
1.1
98.5
11
7
4
1.1
98.5
serum gamma-glutamyl transferase measurement
2
3
3
95.5
Items per page:
1 – 5 of 72
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
98.9
0
1.2
98.9
4
1.1
98.5
4
1.1
98.5
serum gamma-glutamyl transferase measurement
3
95.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DExD-box helicase 52
714492
Mouse
MGI:1925644
78394
Rat
RGD:621743
85432
Dog
DExD-box helicase 52
610374
Horse
DExD-box helicase 52
VGNC:17101
100057718
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DExD-box helicase 52
Mouse
Rat
Dog
DExD-box helicase 52
Horse
DExD-box helicase 52
Publication Statistics
PubMed Score 24.93
PubMed score by year
PubTator Score 2.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title