Tbio DDX52 Probable ATP-dependent RNA helicase DDX52

Protein Summary

Uniprot Accession IDs

• Q9Y2R4
• Q86YG1
• Q8N213
• Q9NVE0
• Q9Y482

Gene Name

• DDX52

Ensembl ID

• ENST00000615769
• ENSP00000480030
• ENSG00000277594
• ENST00000617633
• ENSP00000479504
• ENSG00000278053

Symbol

• ROK1
• ROK1
• HUSSY19

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
virus perturbation	0.99
molecular function	0.94
histone modification site profile	0.85
hub protein	0.82

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.93   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 96   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.93   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (342)

Explore Interacting Targets

1 – 10 of 342

• See Interactions on String-DB

CHCHD4

Tbio

Novelty:  0.01204944

p_int:  0.999450747

p_ni:  0.00054925

p_wrong:  4e-9

Data Source:  BioPlex

DCAF8L2

Tdark

Novelty:  6.73057868

p_int:  0.986956665

p_ni:  0.012592889

p_wrong:  0.000450447

Data Source:  BioPlex

ZNF22

Tbio

Family:  TF

Novelty:  0.12323788

p_int:  0.969988177

p_ni:  0.030011808

p_wrong:  1.5e-8

Score:  0.827

Data Source:  BioPlex,STRINGDB

RPL14

Tbio

Novelty:  0.01600377

p_int:  0.969988177

p_ni:  0.030011808

p_wrong:  1.5e-8

Score:  0.526

Data Source:  BioPlex,STRINGDB

HIST1H1T

Tdark

Novelty:  0.01039464

p_int:  0.969988177

p_ni:  0.030011808

p_wrong:  1.5e-8

Data Source:  BioPlex

CCDC59

Tbio

Novelty:  0.05894885

p_int:  0.955363446

p_ni:  0.044598253

p_wrong:  0.000038301

Score:  0.228

Data Source:  BioPlex,STRINGDB

RPL18

Tbio

Novelty:  0.01765545

p_int:  0.897838408

p_ni:  0.10216159

p_wrong:  2e-9

Data Source:  BioPlex

ZNF324B

Tdark

Family:  TF

Novelty:  1.89922228

p_int:  0.89123879

p_ni:  0.108706729

p_wrong:  0.000054482

Data Source:  BioPlex

GPATCH4

Tdark

Novelty:  1.13040547

p_int:  0.870116783

p_ni:  0.12988267

p_wrong:  5.47e-7

Score:  0.697

Data Source:  BioPlex,STRINGDB

TIMM8A

Tbio

Family:  Enzyme

Novelty:  0.00954602

p_int:  0.84594206

p_ni:  0.154057602

p_wrong:  3.38e-7

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (5)

Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

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1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	rRNA modification in the nucleus and cytosol	59 targets	R-HSA-6790901
Reactome	rRNA processing	217 targets	R-HSA-72312
Reactome	rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773

Name	Explore in Pharos	Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Metabolism of RNA	686 targets	R-HSA-8953854
rRNA modification in the nucleus and cytosol	59 targets	R-HSA-6790901
rRNA processing	217 targets	R-HSA-72312
rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (3)

Components (3)

Processes (1)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
helicase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (72)

Items per page:

5

1 – 5 of 72

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
prostate carcinoma	EFO_0001663	ENSG00000277594	11	5	0	1.2	98.9
prostate carcinoma	EFO_0001663	ENSG00000278053	11	5	0	1.2	98.9
type II diabetes mellitus	EFO_0001360	ENSG00000277594	11	7	4	1.1	98.5
type II diabetes mellitus	EFO_0001360	ENSG00000278053	11	7	4	1.1	98.5
serum gamma-glutamyl transferase measurement	EFO_0004532	ENSG00000277594	2	3	3		95.5

Items per page:

5

1 – 5 of 72

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
prostate carcinoma	EFO_0001663	0	1.2	98.9
prostate carcinoma	EFO_0001663	0	1.2	98.9
type II diabetes mellitus	EFO_0001360	4	1.1	98.5
type II diabetes mellitus	EFO_0001360	4	1.1	98.5
serum gamma-glutamyl transferase measurement	EFO_0004532	3		95.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
ATP-binding
Complete proteome
Helicase
Hydrolase
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
aspartate aminotransferase measurement
benign prostatic hyperplasia
blood urea nitrogen measurement
breast carcinoma
C-reactive protein measurement
cancer
cognitive function measurement
colorectal cancer
Drugs used in diabetes use measurement
endometrial carcinoma

MGI Phenotype Find Similar Targets

No Header	No Header
growth/size/body region phenotype
hematopoietic system phenotype
immune system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	DExD-box helicase 52		714492
Mouse	DEAD (Asp-Glu-Ala-Asp) box polypeptide 52	MGI:1925644	78394
Rat	DExD-box helicase 52	RGD:621743	85432
Dog	DExD-box helicase 52		610374
Horse	DExD-box helicase 52	VGNC:17101	100057718

Species	Name	OMA	EggNOG	Inparanoid
Macaque	DExD-box helicase 52
Mouse	DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
Rat	DExD-box helicase 52
Dog	DExD-box helicase 52
Horse	DExD-box helicase 52

Publication Statistics

PubMed Score 24.93

PubMed score by year

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PubTator Score 2.84

PubTator score by year

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Related Publications

Text Mined References (12)

GeneRif Annotations (2)

Items per page:

10

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PMID	Year	Title