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Tbio
DDX49
Probable ATP-dependent RNA helicase DDX49

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247003
  • ENSP00000247003
  • ENSG00000105671

Symbol
  • Dbp8
  • R27090_2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
molecular function
0.94
histone modification site profile
0.91
kinase perturbation
0.88
protein domain
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.63   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.63   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (413)
RNF19B
Tbio
Family:  Enzyme
Novelty:  0.20054824
p_int:  0.999584201
p_ni:  0.000365802
p_wrong:  0.000049998
Score:  0.199
Data Source:  BioPlex,STRINGDB
EVL
Tbio
Novelty:  0.03533257
p_int:  0.999165077
p_ni:  0.000059193
p_wrong:  0.00077573
Score:  0.197
Data Source:  BioPlex,STRINGDB
PAGE1
Tbio
Novelty:  0.02731969
p_int:  0.997662588
p_ni:  0.000157072
p_wrong:  0.00218034
Score:  0.292
Data Source:  BioPlex,STRINGDB
DHX37
Tdark
Family:  Enzyme
Novelty:  0.02474351
Score:  0.997
Data Source:  STRINGDB
UTP15
Tbio
Novelty:  0.08174586
Score:  0.997
Data Source:  STRINGDB
BYSL
Tbio
Novelty:  0.01919968
Score:  0.997
Data Source:  STRINGDB
IMP4
Tdark
Novelty:  9.64444444
Score:  0.996
Data Source:  STRINGDB
UTP3
Tbio
Novelty:  0.06371711
Score:  0.996
Data Source:  STRINGDB
RRP9
Tbio
Novelty:  0.07232317
Score:  0.995
Data Source:  STRINGDB
DDX52
Tbio
Family:  Enzyme
Novelty:  0.04618463
Score:  0.995
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
1
1
38.1
low density lipoprotein cholesterol measurement
1
1
1
34.9
apolipoprotein B measurement
1
1
1
32.7
triglyceride measurement
1
1
1
15.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
38.1
low density lipoprotein cholesterol measurement
1
34.9
apolipoprotein B measurement
1
32.7
triglyceride measurement
1
15.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 49
VGNC:11993
455866
Macaque
DEAD-box helicase 49
720303
Mouse
MGI:2136689
234374
Rat
RGD:1311124
290660
Dog
DEAD-box helicase 49
VGNC:39861
484814
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 49
Macaque
DEAD-box helicase 49
Mouse
Rat
Dog
DEAD-box helicase 49
Publication Statistics
PubMed Score 8.63
PubMed score by year
PubTator Score 0.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title