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Tbio
DDX46
Probable ATP-dependent RNA helicase DDX46

Protein Summary
Description
Plays an essential role in splicing, either prior to, or during splicing A complex formation. This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354283
  • ENSP00000346236
  • ENSG00000145833

Symbol
  • KIAA0801
  • Prp5
  • PRPF5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
transcription factor perturbation
0.96
molecular function
0.94
interacting protein
0.93
virus perturbation
0.92


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.61   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.61   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (279)
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.999999959
p_ni:  4e-8
p_wrong:  1e-9
Score:  0.152
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999854425
p_ni:  0.000145575
Score:  0.942
Data Source:  BioPlex,STRINGDB
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.998778559
p_ni:  0.001221441
Data Source:  BioPlex
LUC7L2
Tdark
Novelty:  0.36989457
p_int:  0.997556676
p_ni:  0.002443322
p_wrong:  2e-9
Score:  0.442
Data Source:  BioPlex,STRINGDB
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.994546528
p_ni:  0.005453472
Score:  0.915
Data Source:  BioPlex,STRINGDB
PHF5A
Tbio
Family:  Epigenetic
Novelty:  0.02989472
p_int:  0.98866946
p_ni:  0.01133054
Score:  0.968
Data Source:  BioPlex,STRINGDB
MTUS2
Tbio
Novelty:  0.13504593
p_int:  0.935826009
p_ni:  0.064172414
p_wrong:  0.000001577
Score:  0.168
Data Source:  BioPlex,STRINGDB
SNRPB2
Tbio
Novelty:  0.17219587
p_int:  0.910454236
p_ni:  0.089545755
p_wrong:  9e-9
Score:  0.954
Data Source:  BioPlex,STRINGDB
SERPINB5
Tbio
Novelty:  0.00192585
p_int:  0.895054855
p_ni:  0.104943469
p_wrong:  0.000001676
Data Source:  BioPlex
PRPF40A
Tbio
Novelty:  0.00898047
p_int:  0.870548128
p_ni:  0.129448609
p_wrong:  0.000003263
Score:  0.987
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

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1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
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Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
30.2
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 46
VGNC:11917
462070
Macaque
DEAD-box helicase 46
711026
Mouse
MGI:1920895
212880
Rat
RGD:708480
245957
Dog
DEAD-box helicase 46
VGNC:39859
474685
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEAD-box helicase 46
Macaque
DEAD-box helicase 46
Mouse
Rat
Dog
DEAD-box helicase 46
Publication Statistics
PubMed Score 40.61
PubMed score by year
PubTator Score 27.79
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title