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Tbio
DDX4
Probable ATP-dependent RNA helicase DDX4

Protein Summary
Description
ATP-dependent RNA helicase required during spermatogenesis (PubMed:10920202, PubMed:21034600). Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (By similarity). Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs (By similarity). DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353507
  • ENSP00000334167
  • ENSG00000152670
  • ENST00000354991
  • ENSP00000347087
  • ENST00000505374
  • ENSP00000424838
  • ENST00000511853
  • ENSP00000423123
  • ENST00000514278
  • ENSP00000425359

Symbol
  • VASA
  • VASA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
protein domain
0.85
gene perturbation
0.68
cellular component
0.55
cell type or tissue
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.34   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 334   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.34   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0