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Tchem
DDX3X
ATP-dependent RNA helicase DDX3X

Protein Summary
Description
Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. However, the exact mechanisms are not known and some functions may be specific for a subset of mRNAs. Involved in transcriptional regulation. Can enhance transcription from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found associated with the E-cadherin promoter and can down-regulate transcription from the promoter. Involved in regulation of translation initiation. Proposed to be involved in positive regulation of translation such as of cyclin E1/CCNE1 mRNA and specifically of mRNAs containing complex secondary structures in their 5'UTRs; these functions seem to require RNA helicase activity ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000457138
  • ENSP00000392494
  • ENSG00000215301
  • ENST00000478993
  • ENSP00000478443
  • ENST00000629496
  • ENSP00000487224
  • ENST00000629785
  • ENSP00000486516
  • ENST00000630255
  • ENSP00000486720
  • ENST00000644876
  • ENSP00000494040

Symbol
  • DBX
  • DDX3
  • DBX
  • DDX3
  • HLP2
  • DDX14
  • CAP-Rf
  • MRX102
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
interacting protein
1
molecular function
1
virus perturbation
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 377.3   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 632   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 377.3   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 632   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 54
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1