You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
DDX39B
Spliceosome RNA helicase DDX39B

Protein Summary
Description
Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. May undergo several rounds of ATP hydrolysis during assembly of TREX to drive subsequent loading of components such as ALYREF/THOC and CHTOP onto mRNA. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Also associates with pre-mRNA independent of ALYREF/THOC4 and the THO complex. Involved in the nuclear export of intronless mRNA; the ATP- ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000383508
  • ENSP00000373000
  • ENSG00000215425
  • ENST00000396172
  • ENSP00000379475
  • ENSG00000198563
  • ENST00000400295
  • ENSP00000383151
  • ENST00000400296
  • ENSP00000383152
  • ENST00000412106
  • ENSP00000393712
  • ENSG00000225073
  • ENST00000412330
  • ENSP00000398775
  • ENSG00000225859
  • ENST00000413678
  • ENSP00000391463
  • ENSG00000229496
  • ENST00000414440
  • ENSP00000411853
  • ENST00000415689
  • ENSP00000390999
  • ENST00000416863
  • ENSP00000407419
  • ENST00000430784
  • ENSP00000399030
  • ENSG00000235439
  • ENST00000431360
  • ENSP00000404695
  • ENST00000441425
  • ENSP00000388880
  • ENSG00000230624
  • ENST00000445218
  • ENSP00000411136
  • ENST00000448296
  • ENSP00000405560
  • ENST00000453138
  • ENSP00000387994
  • ENST00000456476
  • ENSP00000400326
  • ENST00000456666
  • ENSP00000394160
  • ENST00000458640
  • ENSP00000416269

Symbol
  • BAT1
  • UAP56
  • BAT1
  • UAP56
  • D6S81E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
1
small molecule perturbation
0.99
transcription factor binding site profile
0.88
phenotype
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.25   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.25   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0