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Tbio
DDX39A
ATP-dependent RNA helicase DDX39A

Protein Summary
Description
Isoform 1: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus. This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is thought to play a role in the prognosis of patients with gastrointestinal stromal tumors. A pseudogene of this gene is present on chromosome 13. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242776
  • ENSP00000242776
  • ENSG00000123136
  • ENST00000324340
  • ENSP00000322749
  • ENST00000454233
  • ENSP00000392929
  • ENST00000588692
  • ENSP00000467862

Symbol
  • DDX39
  • BAT1
  • DDXL
  • BAT1L
  • DDX39
  • URH49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
0.97
kinase perturbation
0.96
molecular function
0.95
transcription factor binding site profile
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.61   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.61   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (310)
TERF2
Tchem
Family:  TF
Novelty:  0.01003649
p_int:  0.995034187
p_ni:  0.004965812
p_wrong:  1e-9
Score:  0.244
Data Source:  BioPlex,STRINGDB
FAT4
Tbio
Novelty:  0.01739918
p_int:  0.949784416
p_ni:  0.050215584
Score:  0.226
Data Source:  BioPlex,STRINGDB
FAT3
Tbio
Novelty:  0.03661008
p_int:  0.943491719
p_ni:  0.056508281
Score:  0.186
Data Source:  BioPlex,STRINGDB
TM2D3
Tbio
Novelty:  0.09408834
p_int:  0.907051517
p_ni:  0.092948483
Score:  0.183
Data Source:  BioPlex,STRINGDB
CELSR2
Tbio
Family:  GPCR
Novelty:  0.02657319
p_int:  0.906103321
p_ni:  0.093896679
Score:  0.179
Data Source:  BioPlex,STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.826558594
p_ni:  0.173441406
Score:  0.216
Data Source:  BioPlex,STRINGDB
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.763206311
p_ni:  0.236793689
Score:  0.231
Data Source:  BioPlex,STRINGDB
SARNP
Tbio
Novelty:  0.00987312
Score:  0.997
Data Source:  STRINGDB
ALYREF
Tbio
Novelty:  0.00523802
Score:  0.995
Data Source:  STRINGDB
THOC2
Tbio
Novelty:  0.02886456
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
4
89.8
myeloid white cell count
1
1
1
71.2
lymphocyte count
1
1
1
70.5
leukocyte count
1
1
1
67.7
reticulocyte count
2
1
2
65.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
89.8
myeloid white cell count
1
71.2
lymphocyte count
1
70.5
leukocyte count
1
67.7
reticulocyte count
2
65.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DExD-box helicase 39A
455783
Macaque
DExD-box helicase 39A
718822
Mouse
MGI:1915528
68278
Rat
RGD:619920
89827
Dog
DExD-box helicase 39A
VGNC:39854
476689
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DExD-box helicase 39A
Macaque
DExD-box helicase 39A
Mouse
Rat
Dog
DExD-box helicase 39A
Publication Statistics
PubMed Score 32.61
PubMed score by year
PubTator Score 19.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title